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- catalog contributor b7752312.
- catalog created "c1994.".
- catalog date "1994".
- catalog date "c1994.".
- catalog dateCopyrighted "c1994.".
- catalog description "Dose and affinity are critical for tolerance induction -- Route of antigen administration is critical for successful tolerance induction -- Future therapies must consider B- versus T-cell epitopes -- Designer peptides -- Modification of proteins for reduced antigenicity and persistence in vivo -- Lack of co-stimulation -- Fusion proteins with IgG, with cytokines, and with antibodies targeting certain cells -- Maintenance of unresponsiveness: bone marrow or peripheral expression of tolerogens -- Making choices.".
- catalog description "History: the early years of tolerance -- Tolerance systems defined -- Properties of the unresponsive state -- Nature of the immune response -- Properties of the unresponsive state -- Systems for induction of tolerance: what do they tell us -- Sensitivity of the neonatal period to tolerance induction -- Development of T-cell tolerance in the thymus -- Differential properties of Ta dn B cells in unresponsiveness -- Role of route of exposure in tolerance induction -- Birth, death and resurrection of suppression -- T-cell tolerance to model peptides and alloantigens.".
- catalog description "Includes bibliographical references and index.".
- catalog description "Mechanisms of T-cell tolerance -- From horror autotoxicus to clonal deletion -- Clonal ignorance in the T-cell repertoire -- Evidence for deletion in the T-cell repertoire -- TCR transgenic mice demonstrate deletion of specific T cells -- T-cell clones can be rendered anergic by signal 1 only -- Molecular pathways of T-cell signaling to anergy -- Molecular events leading to apoptosis -- Fitting in T-cell suppression and anti-idiotype circuits -- Which mechanism where? Central versus peripheral tolerance -- Mechanisms of B-cell tolerance.".
- catalog description "Why do we need B-cell tolerance -- Common mechanisms for B- and T-cell tolerance -- Model systems: epitope (hapten) -- specific B-cell unresponsiveness -- Anti-IgM serves as a surrogate for antigen -- Differential roles of IgM and IgD in B-cell signal transduction -- B-cell subset variations in transgenic mice -- B-cell lymphomas as a model for tolerance -- Molecular signals for the induction of tolerance in B cells -- Summary: prospects for application to clinical disease -- Immunologic misconception of birth.".
- catalog extent "116 p. :".
- catalog hasFormat "Nature of immunologic tolerance.".
- catalog identifier "1570591008 :".
- catalog isFormatOf "Nature of immunologic tolerance.".
- catalog isPartOf "Medical intelligence unit (Unnumbered)".
- catalog isPartOf "Medical intelligence unit".
- catalog issued "1994".
- catalog issued "c1994.".
- catalog language "eng".
- catalog publisher "Austin : R.G. Landes ; Boca Raton, FL : Worldwide distributor, CRC Press,".
- catalog relation "Nature of immunologic tolerance.".
- catalog subject "616.07/9 20".
- catalog subject "Immune Tolerance.".
- catalog subject "Immunity, Cellular.".
- catalog subject "Immunological tolerance.".
- catalog subject "QR188.4 .S26 1994".
- catalog subject "QW 504 S425n 1994".
- catalog tableOfContents "Dose and affinity are critical for tolerance induction -- Route of antigen administration is critical for successful tolerance induction -- Future therapies must consider B- versus T-cell epitopes -- Designer peptides -- Modification of proteins for reduced antigenicity and persistence in vivo -- Lack of co-stimulation -- Fusion proteins with IgG, with cytokines, and with antibodies targeting certain cells -- Maintenance of unresponsiveness: bone marrow or peripheral expression of tolerogens -- Making choices.".
- catalog tableOfContents "History: the early years of tolerance -- Tolerance systems defined -- Properties of the unresponsive state -- Nature of the immune response -- Properties of the unresponsive state -- Systems for induction of tolerance: what do they tell us -- Sensitivity of the neonatal period to tolerance induction -- Development of T-cell tolerance in the thymus -- Differential properties of Ta dn B cells in unresponsiveness -- Role of route of exposure in tolerance induction -- Birth, death and resurrection of suppression -- T-cell tolerance to model peptides and alloantigens.".
- catalog tableOfContents "Mechanisms of T-cell tolerance -- From horror autotoxicus to clonal deletion -- Clonal ignorance in the T-cell repertoire -- Evidence for deletion in the T-cell repertoire -- TCR transgenic mice demonstrate deletion of specific T cells -- T-cell clones can be rendered anergic by signal 1 only -- Molecular pathways of T-cell signaling to anergy -- Molecular events leading to apoptosis -- Fitting in T-cell suppression and anti-idiotype circuits -- Which mechanism where? Central versus peripheral tolerance -- Mechanisms of B-cell tolerance.".
- catalog tableOfContents "Why do we need B-cell tolerance -- Common mechanisms for B- and T-cell tolerance -- Model systems: epitope (hapten) -- specific B-cell unresponsiveness -- Anti-IgM serves as a surrogate for antigen -- Differential roles of IgM and IgD in B-cell signal transduction -- B-cell subset variations in transgenic mice -- B-cell lymphomas as a model for tolerance -- Molecular signals for the induction of tolerance in B cells -- Summary: prospects for application to clinical disease -- Immunologic misconception of birth.".
- catalog title "The nature of immunologic tolerance / David W. Scott.".
- catalog type "text".