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- catalog abstract ""Direct and Allosteric Control of Glutamate Receptors describes in detail recent research that has demonstrated that glutamate receptors are subject to numerous modulatory controls. Significant new insights into the physiology and pathophysiology of the nervous system have been obtained by these discoveries. The sites on the receptor proteins where modulation occurs have provided a platform of opportunities for medicinal chemists to design new therapeutic modalities. These new drugs will be of major significance in treating diseases (such as stroke, Alzheimer's, epilepsy, Parkinson's, Huntington's, neurotrauma, schizophrenia, pain, and anxiety) associated with abnormal excitatory amino acid neurotransmission and function."".
- catalog contributor b7878779.
- catalog contributor b7878780.
- catalog contributor b7878781.
- catalog created "c1994.".
- catalog date "1994".
- catalog date "c1994.".
- catalog dateCopyrighted "c1994.".
- catalog description ""Direct and Allosteric Control of Glutamate Receptors describes in detail recent research that has demonstrated that glutamate receptors are subject to numerous modulatory controls. Significant new insights into the physiology and pathophysiology of the nervous system have been obtained by these discoveries. The sites on the receptor proteins where modulation occurs have provided a platform of opportunities for medicinal chemists to design new therapeutic modalities. These new drugs will be of major significance in treating diseases (such as stroke, Alzheimer's, epilepsy, Parkinson's, Huntington's, neurotrauma, schizophrenia, pain, and anxiety) associated with abnormal excitatory amino acid neurotransmission and function."".
- catalog description "(cont) Conantokin-G and its analogs: novel probes of the NMDA receptor associated polyamine site / Phil Skolnick [and others].".
- catalog description "Glutamate receptors and their regulators: an overview / Michael G. Palfreyman -- Molecular pharmacology of mammalian AMPA and kainate receptors / Todd A. Verdoorn -- Calcium, magnesium and glutamate receptors / Ian J. Reynolds, Sunita Rajdev -- Desensitization and the short-term modulation of AMPA/kainate receptors in vertebrate neurons / Charles F. Zorumski, Steven J. Mennerick -- Regulation of glutamate receptors by reversible phosphorylation / John F. MacDonald [and others] -- Redox modulation of the NMDA receptor / Elias Aizenman -- Design and pharmacological evaluation of highly selective glycine antagonists / Bruce M. Baron [and others] -- In vitro and in vivo studies with glycine partial agonists: a novel strategy for preventing NMDA receptor-mediated tissue damage / Kathleen M. Boje -- Neuroprotection by NMDA and non-NMDA glutamate antagonists / Brian S. Meldrum -- Neuroprotective potential of the polyamine site-directed NMDA receptor antagonists: ifenprodil and eliprodil / Bernard Scatton [and others].".
- catalog description "Includes bibliographical references and index.".
- catalog extent "174 p. :".
- catalog identifier "0849383072 (acid-free paper)".
- catalog isPartOf "Pharmacology & toxicology (Boca Raton, Fla.)".
- catalog isPartOf "Pharmacology and toxicology".
- catalog issued "1994".
- catalog issued "c1994.".
- catalog language "eng".
- catalog publisher "Boca Raton : CRC Press,".
- catalog subject "599/.0188 20".
- catalog subject "Allosteric Regulation.".
- catalog subject "Allosteric regulation.".
- catalog subject "Excitatory amino acids Receptors.".
- catalog subject "Glutamic acid Antagonists.".
- catalog subject "Glutamic acid Receptors.".
- catalog subject "QP364.7 .D57 1994".
- catalog subject "QU 55 D598 1994".
- catalog subject "Receptors, Glutamate drug effects.".
- catalog subject "Receptors, Glutamate physiology.".
- catalog tableOfContents "(cont) Conantokin-G and its analogs: novel probes of the NMDA receptor associated polyamine site / Phil Skolnick [and others].".
- catalog tableOfContents "Glutamate receptors and their regulators: an overview / Michael G. Palfreyman -- Molecular pharmacology of mammalian AMPA and kainate receptors / Todd A. Verdoorn -- Calcium, magnesium and glutamate receptors / Ian J. Reynolds, Sunita Rajdev -- Desensitization and the short-term modulation of AMPA/kainate receptors in vertebrate neurons / Charles F. Zorumski, Steven J. Mennerick -- Regulation of glutamate receptors by reversible phosphorylation / John F. MacDonald [and others] -- Redox modulation of the NMDA receptor / Elias Aizenman -- Design and pharmacological evaluation of highly selective glycine antagonists / Bruce M. Baron [and others] -- In vitro and in vivo studies with glycine partial agonists: a novel strategy for preventing NMDA receptor-mediated tissue damage / Kathleen M. Boje -- Neuroprotection by NMDA and non-NMDA glutamate antagonists / Brian S. Meldrum -- Neuroprotective potential of the polyamine site-directed NMDA receptor antagonists: ifenprodil and eliprodil / Bernard Scatton [and others].".
- catalog title "Direct and allosteric control of glutamate receptors / edited by Michael G. Palfreyman, Ian J. Reynolds, Phil Skolnick.".
- catalog type "text".