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- catalog abstract "Cytokines are a steadily growing family of molecules which play a major role in intercellular communication. Key questions for the cytokine researcher today include 'which cytokines are involved in the pathophysiology of a disease or immune response', 'when do these cytokines function' and 'which of their many activities are relevant in vivo'. The intricate ways in which they act, often with the exhibition of pleiotropic or synergistic effects, make the study of cytokine biology complicated, and the results potentially ambiguous using conventional systems. As a consequence, many investigators are now utilizing the powerful tools of transgenic technology to address some of these questions. Written by the leading authorities in the field, this book describes the achievements realized so far, and clearly demonstrates the feasibility of using this approach to study the expression of this group of biologically important substances.".
- catalog contributor b8008870.
- catalog created "c1994.".
- catalog date "1994".
- catalog date "c1994.".
- catalog dateCopyrighted "c1994.".
- catalog description "Cytokines are a steadily growing family of molecules which play a major role in intercellular communication. Key questions for the cytokine researcher today include 'which cytokines are involved in the pathophysiology of a disease or immune response', 'when do these cytokines function' and 'which of their many activities are relevant in vivo'.".
- catalog description "Importance of transforming growth factor-β1 in immunological homeostasis as revealed by gene ablation in mice / M.M. Shull ... [et al.] -- Granulocyte-macrophage colony stimulating factor transgenic mice / D. Metcalf.".
- catalog description "Includes bibliographical references and index.".
- catalog description "Interleukin-6 transgenic mouse: a model of chronic inflammatory proliferative disease / T. Hirano -- Leukemia inhibitory factor and mammalian development / C.L. Stewart -- Lymphopoiesis in mice homozygous for an interleukin-7 transgene: in vivo interactions with abnormal interleukin-4 or c-Kit receptor expression / R. Palacios, J. Samaridis -- Expression and knockout of interferons in transgenic mice / C.O. Jacob -- Human erythropoietin gene expression in transgenic mice / G.L. Semenza.".
- catalog description "Strategies for modulation of interleukin-1 in vivo: knockout and transgenics / F.F. Csaikl, U.M. Csaikl, S.K. Durum -- In situ production of interleukin-2 and its role in autoimmunity / J. Allison, W.R. Heath, J.F.A.P. Miller -- Interleukin-2 overexpression and deprivation: consequences for lymphopoiesis and T cell function / A. Schimpl, T. Hunig -- Interleukin-4 expressing transgenic mice: in vivo models for studying the actions of a cytokine / H.J. Burstein, R.I. Tepper, A.K. Abbas -- Interleukin-5 activity in vivo / C.J. Sanderson, M. Strath.".
- catalog description "The intricate ways in which they act, often with the exhibition of pleiotropic or synergistic effects, make the study of cytokine biology complicated, and the results potentially ambiguous using conventional systems. As a consequence, many investigators are now utilizing the powerful tools of transgenic technology to address some of these questions.".
- catalog description "Written by the leading authorities in the field, this book describes the achievements realized so far, and clearly demonstrates the feasibility of using this approach to study the expression of this group of biologically important substances.".
- catalog extent "xiii, 191 p. :".
- catalog hasFormat "Overexpression and knockout of cytokines in transgenic mice.".
- catalog identifier "0123784506 (alk. paper)".
- catalog isFormatOf "Overexpression and knockout of cytokines in transgenic mice.".
- catalog issued "1994".
- catalog issued "c1994.".
- catalog language "eng".
- catalog publisher "London ; San Diego : Academic Press,".
- catalog relation "Overexpression and knockout of cytokines in transgenic mice.".
- catalog subject "1995 A-644".
- catalog subject "Cellular immunity.".
- catalog subject "Cytokines.".
- catalog subject "Disease Models, Animal.".
- catalog subject "Gene Expression.".
- catalog subject "Genetic engineering.".
- catalog subject "Interleukins genetics.".
- catalog subject "Interleukins immunology.".
- catalog subject "Mice, Knockout.".
- catalog subject "Mice, Transgenic.".
- catalog subject "QH450 .O96 1994".
- catalog subject "T-Lymphocytes immunology.".
- catalog tableOfContents "Importance of transforming growth factor-β1 in immunological homeostasis as revealed by gene ablation in mice / M.M. Shull ... [et al.] -- Granulocyte-macrophage colony stimulating factor transgenic mice / D. Metcalf.".
- catalog tableOfContents "Interleukin-6 transgenic mouse: a model of chronic inflammatory proliferative disease / T. Hirano -- Leukemia inhibitory factor and mammalian development / C.L. Stewart -- Lymphopoiesis in mice homozygous for an interleukin-7 transgene: in vivo interactions with abnormal interleukin-4 or c-Kit receptor expression / R. Palacios, J. Samaridis -- Expression and knockout of interferons in transgenic mice / C.O. Jacob -- Human erythropoietin gene expression in transgenic mice / G.L. Semenza.".
- catalog tableOfContents "Strategies for modulation of interleukin-1 in vivo: knockout and transgenics / F.F. Csaikl, U.M. Csaikl, S.K. Durum -- In situ production of interleukin-2 and its role in autoimmunity / J. Allison, W.R. Heath, J.F.A.P. Miller -- Interleukin-2 overexpression and deprivation: consequences for lymphopoiesis and T cell function / A. Schimpl, T. Hunig -- Interleukin-4 expressing transgenic mice: in vivo models for studying the actions of a cytokine / H.J. Burstein, R.I. Tepper, A.K. Abbas -- Interleukin-5 activity in vivo / C.J. Sanderson, M. Strath.".
- catalog title "Overexpression and knockout of cytokines in transgenic mice / edited by Chaim O. Jacob.".
- catalog type "text".