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• catalog abstract "The thirty-two original contributions in this book provide an up-to-date, interdisciplinary account of current research activity in all aspects of excitatory amino acid transmitters, particularly glutamate and aspartate, in the context of the structure and function of the cerebral cortex in health and in disease. It has recently become clear that the excitatory amino acids and their receptors are critically linked to normal processes of development and synaptic transmission, and to learning and memory, as well as to identifiable disease processes such as Alzheimer's disease, epilepsy, and cortical damage due to stroke/ischemia. Moreover, the pharmacological nature and chemical structures of many of the receptors and binding sites for these synaptic mediators and their modulators are becoming known, thereby enabling the cloning of each receptor subtype. Such advances may help immeasurably in the identification of endogenous ligands for the amino acid receptors and the development of pharmaceuticals and other therapeutic interventions in coming years. The topics are dealt with from electrophysiological, biochemical, anatomical, pharmacological, clinical, and behavioral perspectives to provide a thorough account of the functional roles played by these compounds in the part of the brain dealing with higher processes. The material is broad-based, yet presented in a style that allows clinical and basic scientists alike easy access to integrated material across chapters and between sections.".
• catalog contributor b8991847.
• catalog contributor b8991848.
• catalog created "1996.".
• catalog date "1996".
• catalog date "1996.".
• catalog dateCopyrighted "1996.".
• catalog description "Includes bibliographical references (p. [375]-466) and index.".
• catalog description "Introduction: Why Excitatory Amino Acids and the Cerebral Cortex? -- 1. The Anatomy of the Cerebral Cortex: Aspects of Neuronal Morphology and Organization / Stewart H.C. Hendry -- 2. Diverse Neuronal Functions of the Cerebral Cortex / Barry W. Connors, Manuel A. Castro-Alamancos and Michael Beierlein -- 3. Calcium Channels and the Regulation of Glutamate Exocytosis / David G. Nicholls, David C. Budd, Michael A. Cousin, Brigitte Held, Judith Parkin and Jennifer M. Pocock -- 4. Glutamate Receptor Subunit Composition in Principal Neurons and Interneurons of the Central Nervous System / Maria Vincenza Catania, Jochen Weishaupt, Thorsten Melcher, Jorg R.P. Geiger, Peter Jonas and Hannah Monyer -- 5. Physiology of NMDA Receptors and Synaptic Currents / Shaul Hestrin -- 6. Physiology of AMPA Receptors: Biophysical Characteristics That Subserve Integrative Roles of Synapses / Laurence O. Trussell and Thomas S. Otis.".
• catalog description "It has recently become clear that the excitatory amino acids and their receptors are critically linked to normal processes of development and synaptic transmission, and to learning and memory, as well as to identifiable disease processes such as Alzheimer's disease, epilepsy, and cortical damage due to stroke/ischemia. Moreover, the pharmacological nature and chemical structures of many of the receptors and binding sites for these synaptic mediators and their modulators are becoming known, thereby enabling the cloning of each receptor subtype. Such advances may help immeasurably in the identification of endogenous ligands for the amino acid receptors and the development of pharmaceuticals and other therapeutic interventions in coming years.".
• catalog description "The thirty-two original contributions in this book provide an up-to-date, interdisciplinary account of current research activity in all aspects of excitatory amino acid transmitters, particularly glutamate and aspartate, in the context of the structure and function of the cerebral cortex in health and in disease.".
• catalog description "The topics are dealt with from electrophysiological, biochemical, anatomical, pharmacological, clinical, and behavioral perspectives to provide a thorough account of the functional roles played by these compounds in the part of the brain dealing with higher processes. The material is broad-based, yet presented in a style that allows clinical and basic scientists alike easy access to integrated material across chapters and between sections.".
• catalog extent "xiii, 492 p. :".
• catalog identifier "0262032384 (hc : alk. paper)".
• catalog issued "1996".
• catalog issued "1996.".
• catalog language "eng".
• catalog publisher "Cambridge, Mass. : MIT Press,".
• catalog subject "612.8/25 20".
• catalog subject "Cerebral Cortex.".
• catalog subject "Cerebral cortex.".
• catalog subject "Excitatory Amino Acids.".
• catalog subject "Excitatory amino acids Physiological effect.".
• catalog subject "QP364.7 .E976 1996".
• catalog subject "QV 126 E96 1996".
• catalog tableOfContents "Introduction: Why Excitatory Amino Acids and the Cerebral Cortex? -- 1. The Anatomy of the Cerebral Cortex: Aspects of Neuronal Morphology and Organization / Stewart H.C. Hendry -- 2. Diverse Neuronal Functions of the Cerebral Cortex / Barry W. Connors, Manuel A. Castro-Alamancos and Michael Beierlein -- 3. Calcium Channels and the Regulation of Glutamate Exocytosis / David G. Nicholls, David C. Budd, Michael A. Cousin, Brigitte Held, Judith Parkin and Jennifer M. Pocock -- 4. Glutamate Receptor Subunit Composition in Principal Neurons and Interneurons of the Central Nervous System / Maria Vincenza Catania, Jochen Weishaupt, Thorsten Melcher, Jorg R.P. Geiger, Peter Jonas and Hannah Monyer -- 5. Physiology of NMDA Receptors and Synaptic Currents / Shaul Hestrin -- 6. Physiology of AMPA Receptors: Biophysical Characteristics That Subserve Integrative Roles of Synapses / Laurence O. Trussell and Thomas S. Otis.".
• catalog title "Excitatory amino acids and the cerebral cortex / edited by Fiorenzo Conti and T. Philip Hicks.".
• catalog type "text".