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catalog contributor b10160340.
catalog created "1997.".
catalog date "1997".
catalog date "1997.".
catalog dateCopyrighted "1997.".
catalog description "1. Basic principles of population genetics : 1.1. Introduction ; 1.2. Genetics background ; 1.3. Hardy-Weinberg equilibrium ; 1.4. Linkage equilibrium ; 1.5. Selection ; 1.6. Balance between mutation and selection ; 1.7. Problems -- 2. Counting methods and the EM algorithm : 2.1. Introduction ; 2.2. Gene counting ; 2.3. Description of the EM algorithm ; 2.4. Ascent property of the EM algorithm ; 2.5. Allele frequency estimation by the EM algorithm ; 2.6. Classical segregation analysis by the EM algorithm ; 2.7. Problems -- 3. Newton's method and scoring : 3.1. Introduction ; 3.2. Newton's method ; 3.3. Scoring ; 3.4. Application to the design of linkage experiments ; 3.5. Quasi-Newton methods ; 3.6. The Dirichlet distribution ; 3.7. Empirical Bayes estimation of allele frequencies ; 3.8. Problems -- 4. Hypothesis testing and categorical data : 4.1. Introduction ; 4.2. Hypotheses about genotype frequencies ; 4.3. Other multinomial problems in genetics ; 4.4. The Zmax test ; 4.5. The Wd statistic ; 4.6. Exact tests of independence ; 4.7. Problems -- 5. Genetic identity coefficients : 5.1. Introduction ; 5.2. Kinship and inbreeding coefficients ; 5.3. Condensed identity coefficients ; 5.4. Generalized kinship coefficients ; 5.5. From kinship to identity coefficients ; 5.6. Calculation of generalized kinship coefficients ; 5.7. Problems".
catalog description "11. Radiation hybrid mapping : 11.1. Introduction ; 11.2. Models ; 11.3. Minimum obligate breaks criterion ; 11.4. maximum likelihood methods ; 11.5. Application to haploid data ; 11.6. Polyploid radiation hybrids ; 11.7. Maximum likelihood under polyploidy ; 11.8. Obligate breaks under polyploidy ; 11.9. Bayesian methods ; 11.10. Applications to diploid data ; 11.11. Problems -- 12. Models of recombination : 12.1. Introduction ; 12.2. Mather's formula and its generalization ; 12.3. Count-location model ; 12.4. Stationary renewal models ; 12.5. Poisson-skip model ; 12.6. Chiasma interference ; 12.7. Application to drosophila data ; 12.8. Problems -- 13. Poisson approximation : 13.1. Introduction ; 13.2. Poisson approximation to the Wd statistic ; 13.3. Construction of somatic cell hybrid panels ; 13.4. Biggest marker gap ; 13.5 Randomness of restriction sites ; 13.6. DNA sequence matching ; 13.7. Problems.".
catalog description "6. Applications of identity coefficients : 6.1. Introduction ; 6.2. Genotype prediction ; 6.3. Covariance for a quantitative trait ; 6.4. Risk ratios and genetic model discrimination ; 6.5. An affecteds-only method of linkage analysis ; 6.6. Problems -- 7. Computation of Mendelian likelihoods : 7.1. Introduction ; 7.2. Mendelian models ; 7.3. Genotype elimination and allele consolidation ; 7.4. Array transformations and iterated sums ; 7.5. Array factoring ; 7.6. Examples of pedigree analysis ; 7.7. Problems -- 8. The polygenic model : 8.1. Introduction ; 8.2. Maximum likelihood estimation by scoring ; 8.3. Application to Gc measured genotype data ; 8.4. Multivariate traits ; 8.5. Left and right-hand finger ridge counts ; 8.6. The hypergeometric polygenic model ; 8.7. Application to risk prediction ; 8.8. Problems -- 9. Markov chain Monte Carlo methods : 9.1. Introduction ; 9.2. Review of discrete-time Makov chains ; 9.3. The Hastings-metropolis algorithm and simulated annealing ; 9.4. Descent states and descent graphs ; 9.5. Descent trees and the founder tree graph ; 9.6. The descent graph Markov chain ; 9.7. Computing location scores ; 9.8. Finding a legal descent graph ; 9.9. Haplotyping ; 9.10 Application to episodic ataxia ; 9.11. Problems -- 10. Reconstruction of evolutionary trees : 10.1. Introduction ; 10.2. Evolutionary trees ; 10.3. Maximum parsimony ; 10.4. Review of continuous-time Markov chains ; 10.5. A nucleotide substitution model ; 10.6. Maximum likelihood reconstruction ; 10.7. Origin of the eukaryotes ; 10.8. Problems".
catalog description "Includes bibliographical references and index.".
catalog extent "xii, 265 p. ;".
catalog identifier "0387949097 (hc : alk. paper)".
catalog isPartOf "Statistics for biology and health".
catalog issued "1997".
catalog issued "1997.".
catalog language "eng".
catalog publisher "New York : Springer,".
catalog subject "1997 J-630".
catalog subject "576.5/01/51 21".
catalog subject "Genetic Techniques.".
catalog subject "Genetics Mathematics.".
catalog subject "Genetics Statistical methods.".
catalog subject "Models, Genetic.".
catalog subject "Models, Statistical.".
catalog subject "QH 438.4.M33 L269m 1997".
catalog subject "QH438.4.M33 L36 1997".
catalog tableOfContents "1. Basic principles of population genetics : 1.1. Introduction ; 1.2. Genetics background ; 1.3. Hardy-Weinberg equilibrium ; 1.4. Linkage equilibrium ; 1.5. Selection ; 1.6. Balance between mutation and selection ; 1.7. Problems -- 2. Counting methods and the EM algorithm : 2.1. Introduction ; 2.2. Gene counting ; 2.3. Description of the EM algorithm ; 2.4. Ascent property of the EM algorithm ; 2.5. Allele frequency estimation by the EM algorithm ; 2.6. Classical segregation analysis by the EM algorithm ; 2.7. Problems -- 3. Newton's method and scoring : 3.1. Introduction ; 3.2. Newton's method ; 3.3. Scoring ; 3.4. Application to the design of linkage experiments ; 3.5. Quasi-Newton methods ; 3.6. The Dirichlet distribution ; 3.7. Empirical Bayes estimation of allele frequencies ; 3.8. Problems -- 4. Hypothesis testing and categorical data : 4.1. Introduction ; 4.2. Hypotheses about genotype frequencies ; 4.3. Other multinomial problems in genetics ; 4.4. The Zmax test ; 4.5. The Wd statistic ; 4.6. Exact tests of independence ; 4.7. Problems -- 5. Genetic identity coefficients : 5.1. Introduction ; 5.2. Kinship and inbreeding coefficients ; 5.3. Condensed identity coefficients ; 5.4. Generalized kinship coefficients ; 5.5. From kinship to identity coefficients ; 5.6. Calculation of generalized kinship coefficients ; 5.7. Problems".
catalog tableOfContents "11. Radiation hybrid mapping : 11.1. Introduction ; 11.2. Models ; 11.3. Minimum obligate breaks criterion ; 11.4. maximum likelihood methods ; 11.5. Application to haploid data ; 11.6. Polyploid radiation hybrids ; 11.7. Maximum likelihood under polyploidy ; 11.8. Obligate breaks under polyploidy ; 11.9. Bayesian methods ; 11.10. Applications to diploid data ; 11.11. Problems -- 12. Models of recombination : 12.1. Introduction ; 12.2. Mather's formula and its generalization ; 12.3. Count-location model ; 12.4. Stationary renewal models ; 12.5. Poisson-skip model ; 12.6. Chiasma interference ; 12.7. Application to drosophila data ; 12.8. Problems -- 13. Poisson approximation : 13.1. Introduction ; 13.2. Poisson approximation to the Wd statistic ; 13.3. Construction of somatic cell hybrid panels ; 13.4. Biggest marker gap ; 13.5 Randomness of restriction sites ; 13.6. DNA sequence matching ; 13.7. Problems.".
catalog tableOfContents "6. Applications of identity coefficients : 6.1. Introduction ; 6.2. Genotype prediction ; 6.3. Covariance for a quantitative trait ; 6.4. Risk ratios and genetic model discrimination ; 6.5. An affecteds-only method of linkage analysis ; 6.6. Problems -- 7. Computation of Mendelian likelihoods : 7.1. Introduction ; 7.2. Mendelian models ; 7.3. Genotype elimination and allele consolidation ; 7.4. Array transformations and iterated sums ; 7.5. Array factoring ; 7.6. Examples of pedigree analysis ; 7.7. Problems -- 8. The polygenic model : 8.1. Introduction ; 8.2. Maximum likelihood estimation by scoring ; 8.3. Application to Gc measured genotype data ; 8.4. Multivariate traits ; 8.5. Left and right-hand finger ridge counts ; 8.6. The hypergeometric polygenic model ; 8.7. Application to risk prediction ; 8.8. Problems -- 9. Markov chain Monte Carlo methods : 9.1. Introduction ; 9.2. Review of discrete-time Makov chains ; 9.3. The Hastings-metropolis algorithm and simulated annealing ; 9.4. Descent states and descent graphs ; 9.5. Descent trees and the founder tree graph ; 9.6. The descent graph Markov chain ; 9.7. Computing location scores ; 9.8. Finding a legal descent graph ; 9.9. Haplotyping ; 9.10 Application to episodic ataxia ; 9.11. Problems -- 10. Reconstruction of evolutionary trees : 10.1. Introduction ; 10.2. Evolutionary trees ; 10.3. Maximum parsimony ; 10.4. Review of continuous-time Markov chains ; 10.5. A nucleotide substitution model ; 10.6. Maximum likelihood reconstruction ; 10.7. Origin of the eukaryotes ; 10.8. Problems".
catalog title "Mathematical and statistical methods for genetic analysis / Kenneth Lange.".
catalog type "text".