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- catalog abstract "In this powerful work of conceptual and analytical originality, the author argues for the primacy of the material arrangements of the laboratory in the dynamics of modern molecular biology. In a post-Kuhnian move away from the hegemony of theory, he develops a new epistemology of experimentation in which research is treated as a process for producing epistemic things. These epistemological and historical issues are illuminated in a detailed case study of a particular laboratory, that of the oncologist and biochemist Paul C. Zamecnik and his colleagues, located in a specific setting - the Collis P. Huntington Memorial Hospital of Harvard University at the Massachusetts General Hospital of Boston. The author traces how, between 1945 and 1965, this group developed an experimental system for synthesizing proteins in the test tube that put Zamecnik's research team at the forefront of those who led biochemistry into the era of molecular biology.".
- catalog contributor b10232890.
- catalog created "1997.".
- catalog date "1997".
- catalog date "1997.".
- catalog dateCopyrighted "1997.".
- catalog description "1. After All: An Epistemology of the Beginning -- 2. Experimental Systems and Epistemic Things -- 3. Out of Cancer Research, 1947-50 -- 4. Establishing an In Vitro System of Protein Synthesis, 1949-52 -- 5. Reproduction and Difference -- 6. Defining Fractions, 1952-55 -- 7. Spaces of Representation -- 8. The Activation of Amino Acids, 1954-56 -- 9. Conjunctures, Hybrids, Bifurcations, Experimental Cultures -- 10. Toward Molecular Biology: The Emergence of Soluble RNA, 1955-58 -- 11. Historiality, Narration, and Reflection -- 12. Names Matter: Transfer RNA and Ribosomes, 1958-61 -- 13. Play-off: Messenger RNA and the Genetic Code -- Epilogue: Science and Writing.".
- catalog description "In this powerful work of conceptual and analytical originality, the author argues for the primacy of the material arrangements of the laboratory in the dynamics of modern molecular biology. In a post-Kuhnian move away from the hegemony of theory, he develops a new epistemology of experimentation in which research is treated as a process for producing epistemic things.".
- catalog description "Includes bibliographical references (p. [277]-314) and index.".
- catalog description "These epistemological and historical issues are illuminated in a detailed case study of a particular laboratory, that of the oncologist and biochemist Paul C. Zamecnik and his colleagues, located in a specific setting - the Collis P. Huntington Memorial Hospital of Harvard University at the Massachusetts General Hospital of Boston. The author traces how, between 1945 and 1965, this group developed an experimental system for synthesizing proteins in the test tube that put Zamecnik's research team at the forefront of those who led biochemistry into the era of molecular biology.".
- catalog extent "x, 325 p. :".
- catalog identifier "0804727856 (cloth)".
- catalog identifier "0804727864 (pbk.)".
- catalog isPartOf "Writing science".
- catalog issued "1997".
- catalog issued "1997.".
- catalog language "eng".
- catalog publisher "Stanford, Calif. : Stanford University Press,".
- catalog subject "1998 A-755".
- catalog subject "572/.645/072 21".
- catalog subject "Molecular Biology History.".
- catalog subject "Molecular biology History.".
- catalog subject "Protein Biosynthesis.".
- catalog subject "Proteins History.".
- catalog subject "Proteins Synthesis Methodology Research History.".
- catalog subject "QP551 .R47 1997".
- catalog subject "QU 11.1 R469t 1997".
- catalog subject "Research History.".
- catalog subject "Science Philosophy.".
- catalog tableOfContents "1. After All: An Epistemology of the Beginning -- 2. Experimental Systems and Epistemic Things -- 3. Out of Cancer Research, 1947-50 -- 4. Establishing an In Vitro System of Protein Synthesis, 1949-52 -- 5. Reproduction and Difference -- 6. Defining Fractions, 1952-55 -- 7. Spaces of Representation -- 8. The Activation of Amino Acids, 1954-56 -- 9. Conjunctures, Hybrids, Bifurcations, Experimental Cultures -- 10. Toward Molecular Biology: The Emergence of Soluble RNA, 1955-58 -- 11. Historiality, Narration, and Reflection -- 12. Names Matter: Transfer RNA and Ribosomes, 1958-61 -- 13. Play-off: Messenger RNA and the Genetic Code -- Epilogue: Science and Writing.".
- catalog title "Toward a history of epistemic things : synthesizing proteins in the test tube / Hans-Jörg Rheinberger.".
- catalog type "text".