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- catalog abstract "This book reviews our current level of understanding of the role of genetic instability in human tumorgenesis. In this incredibly rapidly moving field, discoveries in recent years have elucidated a number of important gene products which control cellular responses to DNA damaging agents, such as DNA repair and cell cycle perturbations. Mutations in these genes appear to be important contributors to the development of a significant percentage of human tumors. Furthermore, inherited mutations in some of these genes appear to be responsible for a number of familial cancer susceptibility syndromes and studies of the molecular basis for cancer predisposition in these families have provided many insights into the molecular basis of cancer development. Elucidation of these molecular mechanisms also provides a link between exposures to environmental DNA damaging agents and the genetic changes which result in human cancers. The discussions cover the gamut from scientific insights into genetic instability learned from simple model systems, such as yeast, to the genes which control these processes in human cells and contribute to human tumor development. Such information is being used to develop approaches to reduce cancer development and to provide more specific targets to improve cancer therapies.".
- catalog contributor b10234315.
- catalog created "c1997.".
- catalog date "1997".
- catalog date "c1997.".
- catalog dateCopyrighted "c1997.".
- catalog description "Genetic Instability and Tumorigenesis: Introduction / M.B. Kastan -- Genomic Stability and Instability: A Working Paradigm / K.C. Cheng and L.A. Loeb -- Surveillance and Genome Stability in Budding Yeast: Implications for Mammalian Carcinogenesis / F. Spencer -- Genomic Instability and Its Roles in Neoplasia / T.D. Tlsty -- Role of DNA Excision Repair Gene Defects in the Etiology of Cancer / J.M. Ford and P.C. Hanawalt -- Chromosome Instability Syndromes: Lessons for Carcinogenesis / M.S. Meyn -- Genetic Alterations in Human Tumors / K.R. Cho and L. Hedrick.".
- catalog description "Includes bibliographical references and index.".
- catalog description "The discussions cover the gamut from scientific insights into genetic instability learned from simple model systems, such as yeast, to the genes which control these processes in human cells and contribute to human tumor development. Such information is being used to develop approaches to reduce cancer development and to provide more specific targets to improve cancer therapies.".
- catalog description "This book reviews our current level of understanding of the role of genetic instability in human tumorgenesis. In this incredibly rapidly moving field, discoveries in recent years have elucidated a number of important gene products which control cellular responses to DNA damaging agents, such as DNA repair and cell cycle perturbations. Mutations in these genes appear to be important contributors to the development of a significant percentage of human tumors. Furthermore, inherited mutations in some of these genes appear to be responsible for a number of familial cancer susceptibility syndromes and studies of the molecular basis for cancer predisposition in these families have provided many insights into the molecular basis of cancer development. Elucidation of these molecular mechanisms also provides a link between exposures to environmental DNA damaging agents and the genetic changes which result in human cancers.".
- catalog extent "180 p. :".
- catalog identifier "3540615180".
- catalog isPartOf "Current topics in microbiology and immunology ; 221".
- catalog issued "1997".
- catalog issued "c1997.".
- catalog language "eng".
- catalog publisher "Berlin ; New York : Springer,".
- catalog subject "616.99/4042 21".
- catalog subject "Carcinogenesis Genetic aspects.".
- catalog subject "Chromosome Aberrations.".
- catalog subject "DNA Damage.".
- catalog subject "DNA Repair.".
- catalog subject "DNA repair.".
- catalog subject "Mutagenesis.".
- catalog subject "Neoplasms etiology.".
- catalog subject "Neoplasms genetics.".
- catalog subject "QR1 .E6 vol. 221 RC268.4".
- catalog subject "QZ 202 G3313 1997".
- catalog subject "Tumors Genetic aspects.".
- catalog subject "W1 CU82K v.221 1997".
- catalog tableOfContents "Genetic Instability and Tumorigenesis: Introduction / M.B. Kastan -- Genomic Stability and Instability: A Working Paradigm / K.C. Cheng and L.A. Loeb -- Surveillance and Genome Stability in Budding Yeast: Implications for Mammalian Carcinogenesis / F. Spencer -- Genomic Instability and Its Roles in Neoplasia / T.D. Tlsty -- Role of DNA Excision Repair Gene Defects in the Etiology of Cancer / J.M. Ford and P.C. Hanawalt -- Chromosome Instability Syndromes: Lessons for Carcinogenesis / M.S. Meyn -- Genetic Alterations in Human Tumors / K.R. Cho and L. Hedrick.".
- catalog title "Genetic instability and tumorigenesis / edited by M. B. Kastan.".
- catalog type "text".