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- catalog abstract "Twenty-one papers from the April 1996 Symposium, the first to deal specifically with serine protease inhibitors. The volume is dedicated to the memory of Stuart Stone (1951-1996), whose work at the Friedrich-Miescher Institut in Basel, the University of Cambridge and Monash University in Melbourne helped establish the field. Contributors cover coagulation, neurobiology and cancer, fibrinolysis, development and reproduction, inflammation, and noninhibitor serpins.".
- catalog contributor b10652273.
- catalog contributor b10652274.
- catalog created "c1997.".
- catalog date "1997".
- catalog date "c1997.".
- catalog dateCopyrighted "c1997.".
- catalog description "I. Introduction -- Serpins: from the way it was to the way it is -- Serpins: a mechanistic class of their own -- 2. Coagulation -- Antihrombin: a bloody important serpin -- Heparin cofactor II -- PCI: protein C inhibitor? -- Molecular basis for the resistance of fibrin-bound thrombin to inactivation by heparin/serpin complexes -- 3. Neurobiology and cancer -- Regulation of neurons and astrocytes by thrombin and protease nexin-1: relationship to brain injury -- Maspin: a tumor suppressing serpin -- Proteases and protease inhibitors in tumor progression -- 4. Fibrinolysis -- The role of reactive-center loop mobility in the serpin inhibitory mechanism -- Substrate specificity of tissue type plasminogen activator -- Plasminogen activator inhibitor type-2: a spontaneously polymerizing serpin that exits in two topological forms -- Of mice and men: the function of plasminogen activator inhibitors (PAIs) in vivo -- 5. Development and reproduction -- Biology of progesterone-induced uterine serpins -- Serpins from an insect, manduca sexta -- The significance of serpins in the regulation of proteases in the male genital tract -- 6. Inflammation -- Serpins and programmed cell death -- C1 inhibitor: functional analysis of naturally-occurring mutant proteins -- Serp-1, a poxvirus-encoded serpin, is expressed as a secreted glycoprotein that inhibits the inflammatory response to myxoma virus infection -- Dysfunctional variants and the structural biology of the serpins -- 7. Noninhibitor serpins -- Structure-function studies on PEDF: a noninhibitory serpin with neurotrophic activity -- Colligin, a collagen binding serpin -- 8. Abstracts.".
- catalog description "Includes bibliographical references and index.".
- catalog description "Twenty-one papers from the April 1996 Symposium, the first to deal specifically with serine protease inhibitors. The volume is dedicated to the memory of Stuart Stone (1951-1996), whose work at the Friedrich-Miescher Institut in Basel, the University of Cambridge and Monash University in Melbourne helped establish the field. Contributors cover coagulation, neurobiology and cancer, fibrinolysis, development and reproduction, inflammation, and noninhibitor serpins.".
- catalog extent "xvii, 358 p. :".
- catalog identifier "0306456982".
- catalog isPartOf "Advances in experimental medicine and biology ; v. 425".
- catalog issued "1997".
- catalog issued "c1997.".
- catalog language "eng".
- catalog publisher "New York : Plenum Press,".
- catalog subject "612/.01575 21".
- catalog subject "QP607.S47 C48 1997".
- catalog subject "QU 136 C517 1997".
- catalog subject "Serpins Congresses.".
- catalog subject "Serpins Pathophysiology Congresses.".
- catalog subject "Serpins Physiological effect Congresses.".
- catalog subject "Serpins physiology congresses.".
- catalog subject "W1 AD559 v.425 1997".
- catalog tableOfContents "I. Introduction -- Serpins: from the way it was to the way it is -- Serpins: a mechanistic class of their own -- 2. Coagulation -- Antihrombin: a bloody important serpin -- Heparin cofactor II -- PCI: protein C inhibitor? -- Molecular basis for the resistance of fibrin-bound thrombin to inactivation by heparin/serpin complexes -- 3. Neurobiology and cancer -- Regulation of neurons and astrocytes by thrombin and protease nexin-1: relationship to brain injury -- Maspin: a tumor suppressing serpin -- Proteases and protease inhibitors in tumor progression -- 4. Fibrinolysis -- The role of reactive-center loop mobility in the serpin inhibitory mechanism -- Substrate specificity of tissue type plasminogen activator -- Plasminogen activator inhibitor type-2: a spontaneously polymerizing serpin that exits in two topological forms -- Of mice and men: the function of plasminogen activator inhibitors (PAIs) in vivo -- 5. Development and reproduction -- Biology of progesterone-induced uterine serpins -- Serpins from an insect, manduca sexta -- The significance of serpins in the regulation of proteases in the male genital tract -- 6. Inflammation -- Serpins and programmed cell death -- C1 inhibitor: functional analysis of naturally-occurring mutant proteins -- Serp-1, a poxvirus-encoded serpin, is expressed as a secreted glycoprotein that inhibits the inflammatory response to myxoma virus infection -- Dysfunctional variants and the structural biology of the serpins -- 7. Noninhibitor serpins -- Structure-function studies on PEDF: a noninhibitory serpin with neurotrophic activity -- Colligin, a collagen binding serpin -- 8. Abstracts.".
- catalog title "Chemistry and biology of serpins / edited by Frank C. Church ... [et al.].".
- catalog type "text".