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- catalog abstract "Therapeutic Applications of Ribozymes, expert laboratory scientists describe in detail their methodologies for constructing ribozymes designed to elucidate the role of specific genes as key routes to the development of novel therapies for a wide variety of diseases. The authors review the many sites targeted with ribozymes in various diseases and provide specific accounts of the practical techniques required for the proper use of ribozymes in these systems. Their cutting-edge protocols demonstrate how to achieve ribozyme expression in distinct cellular systems, the preparation and use of high-efficiency ribozyme DNA or RNA delivery, and the studies required to prove the efficacy of ribozyme-mediated inhibition, with its concomitant effect on phenotypic parameters. Therapeutic Applications of Ribozymes contains all the practical detail necessary to realize the high promise of ribozyme technology as a significant, widely used methodology. Focused on ribozyme targets and the novel associated technology, the book immediately becomes the leading resource for all those seeking to transform this new category of therapeutic agent into efficacious clinical practice.".
- catalog contributor b10868340.
- catalog created "c1998.".
- catalog date "1998".
- catalog date "c1998.".
- catalog dateCopyrighted "c1998.".
- catalog description "1. Small Efficient Hammerhead Ribozymes / Philip Hendry, Trevor J. Lockett and Maxine J. McCall -- 2. The Hairpin Ribozyme: Discovery and Development for Gene Therapy / Arnold Hampel -- 3. Molecular Manipulations of the Catalytic RNAs from the Human Hepatitis Delta Virus / N. Kyle Tanner -- 4. The Design, Production, and Validation of an Anti-HIV Type 1 Ribozyme / Lun-Quan Sun, Wayne Gerlach and Geoff Symonds -- 5. Methods for Treating HIV by Gene Therapy Using Ribozymes / Eric M. Poeschla, Mang Yu and Mark C. Leavitt [and others] -- 6. An Expression Vector for Multiple Ribozymes / Jun Ohkawa, Yutaka Takebe and Kazunari Taira -- 7. Viral RNA Targets for Ribozymes: Influenza A Virus / Gerd Hobom and Annette Menke.".
- catalog description "Includes bibliographical references and index.".
- catalog description "Therapeutic Applications of Ribozymes contains all the practical detail necessary to realize the high promise of ribozyme technology as a significant, widely used methodology. Focused on ribozyme targets and the novel associated technology, the book immediately becomes the leading resource for all those seeking to transform this new category of therapeutic agent into efficacious clinical practice.".
- catalog description "Therapeutic Applications of Ribozymes, expert laboratory scientists describe in detail their methodologies for constructing ribozymes designed to elucidate the role of specific genes as key routes to the development of novel therapies for a wide variety of diseases. The authors review the many sites targeted with ribozymes in various diseases and provide specific accounts of the practical techniques required for the proper use of ribozymes in these systems. Their cutting-edge protocols demonstrate how to achieve ribozyme expression in distinct cellular systems, the preparation and use of high-efficiency ribozyme DNA or RNA delivery, and the studies required to prove the efficacy of ribozyme-mediated inhibition, with its concomitant effect on phenotypic parameters.".
- catalog extent "xiv, 462 p. :".
- catalog hasFormat "Therapeutic applications of ribozymes.".
- catalog identifier "0896034771 (alk. paper)".
- catalog isFormatOf "Therapeutic applications of ribozymes.".
- catalog isPartOf "Methods in molecular medicine ; 11".
- catalog issued "1998".
- catalog issued "c1998.".
- catalog language "eng".
- catalog publisher "Totowa, N.J. : Humana Press,".
- catalog relation "Therapeutic applications of ribozymes.".
- catalog subject "616/.042 21".
- catalog subject "Catalytic RNA Laboratory manuals.".
- catalog subject "Catalytic RNA Therapeutic use.".
- catalog subject "Genetic Therapy methods".
- catalog subject "QU 58.7 T398 1998".
- catalog subject "RM666.R554 T47 1998".
- catalog subject "RNA, Catalytic therapeutic use".
- catalog tableOfContents "1. Small Efficient Hammerhead Ribozymes / Philip Hendry, Trevor J. Lockett and Maxine J. McCall -- 2. The Hairpin Ribozyme: Discovery and Development for Gene Therapy / Arnold Hampel -- 3. Molecular Manipulations of the Catalytic RNAs from the Human Hepatitis Delta Virus / N. Kyle Tanner -- 4. The Design, Production, and Validation of an Anti-HIV Type 1 Ribozyme / Lun-Quan Sun, Wayne Gerlach and Geoff Symonds -- 5. Methods for Treating HIV by Gene Therapy Using Ribozymes / Eric M. Poeschla, Mang Yu and Mark C. Leavitt [and others] -- 6. An Expression Vector for Multiple Ribozymes / Jun Ohkawa, Yutaka Takebe and Kazunari Taira -- 7. Viral RNA Targets for Ribozymes: Influenza A Virus / Gerd Hobom and Annette Menke.".
- catalog title "Therapeutic applications of ribozymes / edited by Kevin J. Scanlon.".
- catalog type "Handbooks, manuals, etc. fast".
- catalog type "text".