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- catalog abstract ""Why do we age? Is aging inevitable? Will advances in medical knowledge allow us to extend the human lifespan beyond its present limits? Recent discoveries in the fields of cell biology and molecular genetics are seriously challenging the assumption that human lifespans are beyond our control." "With such discoveries in mind, noted cell biologist William R. Clark describes how senescence begins at the level of individual cells and how cellular replication may be bound up with aging of the entire organism. He explores the evolutionary origin and function of aging, the cellular connections between aging and cancer, the parallels between cellular senescence and Alzheimer's disease, and the insights gained through studying human genetic disorders - such as Werner's syndrome - that mimic the symptoms of aging. Clark also explains how reduction in caloric intake may actually help increase lifespan, and how the destructive effects of oxidative elements in the body may be limited by the consumption of antioxidants found in fruits and vegetables. In a final chapter, Clark considers the social and economic aspects of living longer, the implications of gene therapy on senescence, and what we might learn about aging from experiments in cloning."--Jacket.".
- catalog contributor b11275068.
- catalog created "1999.".
- catalog date "1999".
- catalog date "1999.".
- catalog dateCopyrighted "1999.".
- catalog description ""Why do we age? Is aging inevitable? Will advances in medical knowledge allow us to extend the human lifespan beyond its present limits? Recent discoveries in the fields of cell biology and molecular genetics are seriously challenging the assumption that human lifespans are beyond our control." "With such discoveries in mind, noted cell biologist William R. Clark describes how senescence begins at the level of individual cells and how cellular replication may be bound up with aging of the entire organism. He explores the evolutionary origin and function of aging, the cellular connections between aging and cancer, the parallels between cellular senescence and Alzheimer's disease, and the insights gained through studying human genetic disorders - such as Werner's syndrome - that mimic the symptoms of aging. Clark also explains how reduction in caloric intake may actually help increase lifespan, and how the destructive effects of oxidative elements in the body may be limited by the consumption of antioxidants found in fruits and vegetables. In a final chapter, Clark considers the social and economic aspects of living longer, the implications of gene therapy on senescence, and what we might learn about aging from experiments in cloning."--Jacket.".
- catalog description "Aging, senescence, and lifespan -- The nature of cellular senescence and death -- The evolution of senescence and death -- Of embryos and worms and very old men: the developmental genetics of senescence and lifespan -- Human genetic diseases that mimic the aging process -- Cycling to senescence -- Replicative immortality: cancer and aging -- Caloric restriction and maximum lifespan -- With every breath we take: oxidative stress and celluar senescence -- The aging brain -- A conditional benefit.".
- catalog description "Includes bibliographical references (p. [221]-228) and index.".
- catalog extent "xv, 234 p. :".
- catalog identifier "0195125932 (acid-free paper)".
- catalog issued "1999".
- catalog issued "1999.".
- catalog language "eng".
- catalog publisher "New York : Oxford University Press,".
- catalog subject "1999 E-578".
- catalog subject "612.6/7 21".
- catalog subject "Aging physiology.".
- catalog subject "Apoptosis.".
- catalog subject "Cell Aging.".
- catalog subject "Cell Death.".
- catalog subject "Cells Aging.".
- catalog subject "QH608 .C53 1999".
- catalog subject "WT 104 C596m 1999".
- catalog tableOfContents "Aging, senescence, and lifespan -- The nature of cellular senescence and death -- The evolution of senescence and death -- Of embryos and worms and very old men: the developmental genetics of senescence and lifespan -- Human genetic diseases that mimic the aging process -- Cycling to senescence -- Replicative immortality: cancer and aging -- Caloric restriction and maximum lifespan -- With every breath we take: oxidative stress and celluar senescence -- The aging brain -- A conditional benefit.".
- catalog title "A means to an end : the biological basis of aging and death / William R. Clark.".
- catalog type "text".