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• catalog abstract "This volume includes the contributions presented at the Second International Symposium on Nutrition and Cancer. During this Conference, experts from different disciplines faced pivotal and timely questions on the interactions between human nutrition and the development of malignancies. The major scientific advancements in the last six years derive from the extensive use of molecular approaches to perform research in the nutritional field. Moreover, the fundamental observation of R. Doll and R. Peto (1981), which suggested that at least 35% of all cancers (with large differences among different tumors) might be prevented by dietary regimens, has been definitively confirmed by epidemiological studies. However, the relationships between diet and cancer are quite intricate and complex; it is difficult, and, not methodologically correct, to reduce them to simple terms: metabolic and hormonal factors, contaminants and biological agents, and deficiency of specific protective nutrients are all components of the same puzzle. The molecular studies reported in this volume include all of the major aspects of investigation on human nutrition and malignant transformation. In the last decade a large number of compounds responsible for the biological activity of human foods have been identified and characterized. These molecules not only include important and well-known risk factors but, most promising, compounds, which might exert chemopreventive activity. Among them, antioxidants (such as vitamins, phenols, and lycopene) seem to play a critical role in reducing the risk of cancer at different anatomical sites, including colon, breast, and prostate malignancies. Other molecules, derived from fiber bacterial intestinal degradation (short fatty acids), are of interest, even if their importance has not been completely unravelled and is still the subject of debate. The relevance of the individual genetic background, as an independent risk factor also in the development of diet-related cancer, opens new perspectives for molecular epidemiology. The working hypothesis is that genetic differences in the metabolism of nutrients might result in a different incidence of malignancies. A further development in the genetic field is the understanding of mechanisms involved in the repair of DNA alterations. Also in this case, the occurrence of genetic polymorphisms might result in distinct responses to identical dietary risk factors. A further promising advancement relates to the finding that active dietary molecules might regulate cell transduction pathways and gene expression and, in turn, cell proliferation and differentiation. In recent years, the precise knowledge of the principal protein players of cell division cycle machinery has allowed the elucidation of the growth biochemistry. A number of recent data suggest that dietary-derived compounds, including radical scavengers, affect cell proliferation by acting on the cell division cycle engine and thus might control the process (and the rate) of malignant transformation. The above themes are described in this new volume, but the final word on their true importance must wait until the dust of the present time has settled. What we can anticipate is that the rapid development of new methodologies and the convergence of different types of approaches (molecular, epidemiological, intervention) to clarify the relationship between Nutrition and Cancer will require new appraisal, with continuous updating, on this central aspect of human health.".
• catalog contributor b11620446.
• catalog contributor b11620447.
• catalog created "c1999.".
• catalog date "1999".
• catalog date "c1999.".
• catalog dateCopyrighted "c1999.".
• catalog description "Epidemiological Studies: Risk Factors and Diets -- Diet and Cancer: Perspectives of Prevention / Peter Greenwald -- EPIC-Italy: A Molecular Epidemiology Project on Diet and Cancer / Domenico Palli, Vittorio Krogh, Antonio Russo, Franco Berrino, Salvatore Panico, Rosario Tumino, Paolo Vineis -- Nutritional Factors in Human Cancers / Edward Giovannucci -- Alcohol and Cancer / Silvia Franceschi -- Energy Sources and Risk of Cancer of the Breast and Colon-Rectum in Italy / Adriano Favero, Maria Parpinel, Maurizio Montella -- Organochlorines and Breast Cancer: A Study on Neapolitan Women / Rossano Dello Iacovo, Egidio Celentano, Anna Maria Strollo, Giacomo Iazzetta, Immacolata Capasso, Giacomo Randazzo -- Olive Oil Consumption and Cancer Mortality in Italy: A Correlation Study / Amleto D'Amicis, Sara Farchi -- Cell Growth and Differentiation: Molecular Bases of Nutrient Effects -- Cell Division Cycle Alterations and Human Tumors / Fulvio Della Ragione, Adriana Borriello, Valentina Della Pietra, Valeria Cucciolla, Adriana Oliva, Alfonso Barbarisi, Achille Iolascon, Vincenzo Zappia -- Regulation of p53 Function in Normal and Malignant Cells / Vincenzo Tortora, Paola Bontempo, Mariantonietta Verdicchio, Ignazio Armetta, Ciro Abbondanza, Ettore Maria Schiavone, Ernesto Nola, Giovanni Alfredo Puca, Anna Maria Molinari -- The Role of Micronutrients in DNA Synthesis and Maintenance / Robert A. Jacob.".
• catalog description "However, the relationships between diet and cancer are quite intricate and complex; it is difficult, and, not methodologically correct, to reduce them to simple terms: metabolic and hormonal factors, contaminants and biological agents, and deficiency of specific protective nutrients are all components of the same puzzle. The molecular studies reported in this volume include all of the major aspects of investigation on human nutrition and malignant transformation. In the last decade a large number of compounds responsible for the biological activity of human foods have been identified and characterized. These molecules not only include important and well-known risk factors but, most promising, compounds, which might exert chemopreventive activity. Among them, antioxidants (such as vitamins, phenols, and lycopene) seem to play a critical role in reducing the risk of cancer at different anatomical sites, including colon, breast, and prostate malignancies. ".
• catalog description "In recent years, the precise knowledge of the principal protein players of cell division cycle machinery has allowed the elucidation of the growth biochemistry. A number of recent data suggest that dietary-derived compounds, including radical scavengers, affect cell proliferation by acting on the cell division cycle engine and thus might control the process (and the rate) of malignant transformation. The above themes are described in this new volume, but the final word on their true importance must wait until the dust of the present time has settled. What we can anticipate is that the rapid development of new methodologies and the convergence of different types of approaches (molecular, epidemiological, intervention) to clarify the relationship between Nutrition and Cancer will require new appraisal, with continuous updating, on this central aspect of human health.".
• catalog description "Includes bibliographical references and index.".
• catalog description "Other molecules, derived from fiber bacterial intestinal degradation (short fatty acids), are of interest, even if their importance has not been completely unravelled and is still the subject of debate. The relevance of the individual genetic background, as an independent risk factor also in the development of diet-related cancer, opens new perspectives for molecular epidemiology. The working hypothesis is that genetic differences in the metabolism of nutrients might result in a different incidence of malignancies. A further development in the genetic field is the understanding of mechanisms involved in the repair of DNA alterations. Also in this case, the occurrence of genetic polymorphisms might result in distinct responses to identical dietary risk factors. A further promising advancement relates to the finding that active dietary molecules might regulate cell transduction pathways and gene expression and, in turn, cell proliferation and differentiation. ".
• catalog description "This volume includes the contributions presented at the Second International Symposium on Nutrition and Cancer. During this Conference, experts from different disciplines faced pivotal and timely questions on the interactions between human nutrition and the development of malignancies. The major scientific advancements in the last six years derive from the extensive use of molecular approaches to perform research in the nutritional field. Moreover, the fundamental observation of R. Doll and R. Peto (1981), which suggested that at least 35% of all cancers (with large differences among different tumors) might be prevented by dietary regimens, has been definitively confirmed by epidemiological studies. ".
• catalog extent "xi, 313 p. :".
• catalog identifier "0306463067".
• catalog isPartOf "Advances in experimental medicine and biology ; v. 472".
• catalog issued "1999".
• catalog issued "c1999.".
• catalog language "eng".
• catalog publisher "New York : Kluwer Academic/Plenum,".
• catalog subject "616.99/4071 21".
• catalog subject "Cancer Nutritional aspects Congresses.".
• catalog subject "Cell Transformation, Neoplastic genetics".
• catalog subject "Diet Congresses.".
• catalog subject "Diet.".
• catalog subject "Neoplasms epidemiology".
• catalog subject "Neoplasms etiology Congresses.".
• catalog subject "Neoplasms etiology".
• catalog subject "Neoplasms prevention & control Congresses.".
• catalog subject "Nutritional Physiological Phenomena Congresses.".
• catalog subject "QZ 202 A24452 1999".
• catalog subject "RC268.45 .A38 2000".
• catalog subject "Risk Factors Congresses.".
• catalog subject "W1 AD559 v.472 1999".
• catalog tableOfContents "Epidemiological Studies: Risk Factors and Diets -- Diet and Cancer: Perspectives of Prevention / Peter Greenwald -- EPIC-Italy: A Molecular Epidemiology Project on Diet and Cancer / Domenico Palli, Vittorio Krogh, Antonio Russo, Franco Berrino, Salvatore Panico, Rosario Tumino, Paolo Vineis -- Nutritional Factors in Human Cancers / Edward Giovannucci -- Alcohol and Cancer / Silvia Franceschi -- Energy Sources and Risk of Cancer of the Breast and Colon-Rectum in Italy / Adriano Favero, Maria Parpinel, Maurizio Montella -- Organochlorines and Breast Cancer: A Study on Neapolitan Women / Rossano Dello Iacovo, Egidio Celentano, Anna Maria Strollo, Giacomo Iazzetta, Immacolata Capasso, Giacomo Randazzo -- Olive Oil Consumption and Cancer Mortality in Italy: A Correlation Study / Amleto D'Amicis, Sara Farchi -- Cell Growth and Differentiation: Molecular Bases of Nutrient Effects -- Cell Division Cycle Alterations and Human Tumors / Fulvio Della Ragione, Adriana Borriello, Valentina Della Pietra, Valeria Cucciolla, Adriana Oliva, Alfonso Barbarisi, Achille Iolascon, Vincenzo Zappia -- Regulation of p53 Function in Normal and Malignant Cells / Vincenzo Tortora, Paola Bontempo, Mariantonietta Verdicchio, Ignazio Armetta, Ciro Abbondanza, Ettore Maria Schiavone, Ernesto Nola, Giovanni Alfredo Puca, Anna Maria Molinari -- The Role of Micronutrients in DNA Synthesis and Maintenance / Robert A. Jacob.".
• catalog title "Advances in nutrition and cancer 2 / edited by Vincenzo Zappia ... [et al.].".
• catalog type "Conference proceedings. fast".
• catalog type "Congresses".
• catalog type "text".