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catalog abstract "Yvonne and Christopher Barnett and a team of recognized international experts detail key biochemical, analytical, and molecular techniques for the investigation of aging at the cellular, tissue, organ, and whole system levels. These cutting-edge methods address a wide range of research needs, from uncovering the factors associated with cell senescence and death, to exploring alterations in the body's ability both to metabolize xenobiotics and to defend itself against biomolecular damage. State-of-the-art protocols also measure the morphological, functional, and molecular changes that accumulate within mitochrondria over time, and permit the genetic and functional characteristics of the immune system to be determined. Wide ranging and highly practical, Aging Methods and Protocols provides today's molecular gerontologists, pharmacologists, and clinical investigators with a gold-standard collection of readily reproducible techniques for identifying those key cellular and molecular processes that might one day make it possible to regulate the aging process. (Publisher's Description).".
catalog contributor b11694479.
catalog contributor b11694480.
catalog created "c2000.".
catalog date "2000".
catalog date "c2000.".
catalog dateCopyrighted "c2000.".
catalog description "1. Understanding Aging / Bernard L. Strehler -- pt. I. Study of Cell Senescence and Cell Death -- 2. Use of the Fibroblast Model in the Study of Cellular Senescence / Vincent J. Cristofalo, Craig Volker and Robert G. Allen -- 3. Human T-Cell Clones / Graham Pawelec -- 4. Telomeres and Replicative Senescence / Hector F. Valenzuela and Rita B. Effros -- 5. Detection of Molecular Events During Apoptosis by Flow Cytometry / Ruaidhri J. Carmody, Ana P. Costa-Pereira and Sharon L. McKenna / [and others] -- 6. Raf-1 Protein Kinase Activity in T Cells from Aged Mice / Christopher J. Kirk and Richard A. Miller -- 7. Identification of Differentially Expressed Genes in Young and Senescent T Cells / Andrea Engel, Mahdi Adibzadeh and Graham Pawelec -- pt. II. Age-Related Changes to Xenobiotic Metabolizing Enzyme Systems -- 8. Xenobiotic-Metabolizing Enzyme Systems and Aging / Christopher R. Barnett and Costas Ioannides -- pt. III.".
catalog description "14. Somatic Mutations and Aging: Methods for Molecular Analysis of HPRT Mutations / Sai-Mei Hou -- 15. Assessment of Susceptibility of Low-Density Lipoprotein to Oxidation / Jane McEneny and Ian S. Young -- 16. Measurement of Pentosidine in Biological Samples / Jesus R. Requena, David L. Price and Suzanne R. Thorpe / [et al.] -- pt. V. Mitochondrial Morphology, Function and Mutation with Age -- 17. Causes and Consequences of Damage to Mitochondria: Morphological Aspects / Jaime Miquel and Carlo Bertoni-Freddari -- 18. Causes and Consequences of Damage to Mitochondria: Study of Functional Aspects by Flow Cytometry / Federico V. Pallardo, Juan Sastre and Jaime Miquel / [et al.] -- 19. Analysis of Mitochondrial DNA Mutations: Deletions / Robert W. Taylor, Theresa M. Wardell and Emma L. Blakely / [et al.] -- 20. Analysis of Mitochondrial DNA Mutations: Point Mutations / Robert W. Taylor, Richard M. Andrews and Patrick F. Chinnery /".
catalog description "Age-Related Changes to Defense Systems Against Biomolecule Damage -- 9. Assessing Age-Related Changes in Antioxidant Status: The FRASC Assay for Total Antioxidant Power and Ascorbic Acid Concentration in Biological Fluids / Iris F.F. Benzie and John J. Strain -- 10. Measurement of DNA Damage and Repair Capacity as a Function of Age Using the Comet Assay / Peter H. Clingen, Jillian E. Lowe and Michael H.L. Green -- 11. Measurement of DNA Damage and Repair in Human White Blood Cells by an Immunochemical Assay / Govert P. van der Schans -- pt. IV. Age-Related Changes to Cellular Biomolecules -- 12. Measurement of 8-Oxo-deoxyguanosine in Lymphocytes, Cultured Cells, and Tissue Samples by HPLC with Electrochemical Detection / Sharon G. Wood, Catherine M. Gedik and Nicholas J. Vaughan / [et al.] -- 13. Mutation and the Aging Process: Mutant Frequency at the HPRT Gene Locus as a Function of Age in Humans / Yvonne A. Barnett and Christopher R. Barnett --".
catalog description "Includes bibliographical references and index.".
catalog description "Yvonne and Christopher Barnett and a team of recognized international experts detail key biochemical, analytical, and molecular techniques for the investigation of aging at the cellular, tissue, organ, and whole system levels. These cutting-edge methods address a wide range of research needs, from uncovering the factors associated with cell senescence and death, to exploring alterations in the body's ability both to metabolize xenobiotics and to defend itself against biomolecular damage. State-of-the-art protocols also measure the morphological, functional, and molecular changes that accumulate within mitochrondria over time, and permit the genetic and functional characteristics of the immune system to be determined. Wide ranging and highly practical, Aging Methods and Protocols provides today's molecular gerontologists, pharmacologists, and clinical investigators with a gold-standard collection of readily reproducible techniques for identifying those key cellular and molecular processes that might one day make it possible to regulate the aging process. (Publisher's Description).".
catalog description "[et al.] -- pt. VI. Immune System and Aging -- 21. Assessment of T-Cell Function in the Aged: T-Cell Proliferative and T-Cell Adherence Assays / Ian Beckman -- 22. Dendritic Cells in Old Age / Beatrix Grubeck-Loebenstein, Maria Saurwein-Teissl and Nikolaus Romani -- 23. Age-Related Alterations to Natural Killer Cell Function / Erminia Mariani, Corona Alonso and Rafael Solana -- 24. Immunogenetics and Life-Span: HLA / Derek Middleton, Martin D. Curran and Fionnuala Williams -- pt. VII. Case Studies -- 25. Dietary Restriction and Life-Span Extension / Byung Pal Yu -- 26. Use of Genetically Engineered Mice in Aging Research / Julie K. Andersen.".
catalog extent "xiv, 385 p. :".
catalog hasFormat "Aging methods and protocols.".
catalog identifier "0896035824".
catalog isFormatOf "Aging methods and protocols.".
catalog isPartOf "Methods in molecular medicine ; 38".
catalog issued "2000".
catalog issued "c2000.".
catalog language "eng".
catalog publisher "Totowa, NJ : Humana Press,".
catalog relation "Aging methods and protocols.".
catalog subject "2000 I-049".
catalog subject "571.8/78 21".
catalog subject "Aging Molecular aspects Laboratory manuals.".
catalog subject "Aging physiology Laboratory Manuals.".
catalog subject "Aging physiology.".
catalog subject "QP86 .A375 1999".
catalog subject "Research Design Laboratory Manuals.".
catalog subject "Research methods".
catalog subject "WT 25 A267 2000".
catalog tableOfContents "1. Understanding Aging / Bernard L. Strehler -- pt. I. Study of Cell Senescence and Cell Death -- 2. Use of the Fibroblast Model in the Study of Cellular Senescence / Vincent J. Cristofalo, Craig Volker and Robert G. Allen -- 3. Human T-Cell Clones / Graham Pawelec -- 4. Telomeres and Replicative Senescence / Hector F. Valenzuela and Rita B. Effros -- 5. Detection of Molecular Events During Apoptosis by Flow Cytometry / Ruaidhri J. Carmody, Ana P. Costa-Pereira and Sharon L. McKenna / [and others] -- 6. Raf-1 Protein Kinase Activity in T Cells from Aged Mice / Christopher J. Kirk and Richard A. Miller -- 7. Identification of Differentially Expressed Genes in Young and Senescent T Cells / Andrea Engel, Mahdi Adibzadeh and Graham Pawelec -- pt. II. Age-Related Changes to Xenobiotic Metabolizing Enzyme Systems -- 8. Xenobiotic-Metabolizing Enzyme Systems and Aging / Christopher R. Barnett and Costas Ioannides -- pt. III.".
catalog tableOfContents "14. Somatic Mutations and Aging: Methods for Molecular Analysis of HPRT Mutations / Sai-Mei Hou -- 15. Assessment of Susceptibility of Low-Density Lipoprotein to Oxidation / Jane McEneny and Ian S. Young -- 16. Measurement of Pentosidine in Biological Samples / Jesus R. Requena, David L. Price and Suzanne R. Thorpe / [et al.] -- pt. V. Mitochondrial Morphology, Function and Mutation with Age -- 17. Causes and Consequences of Damage to Mitochondria: Morphological Aspects / Jaime Miquel and Carlo Bertoni-Freddari -- 18. Causes and Consequences of Damage to Mitochondria: Study of Functional Aspects by Flow Cytometry / Federico V. Pallardo, Juan Sastre and Jaime Miquel / [et al.] -- 19. Analysis of Mitochondrial DNA Mutations: Deletions / Robert W. Taylor, Theresa M. Wardell and Emma L. Blakely / [et al.] -- 20. Analysis of Mitochondrial DNA Mutations: Point Mutations / Robert W. Taylor, Richard M. Andrews and Patrick F. Chinnery /".
catalog tableOfContents "Age-Related Changes to Defense Systems Against Biomolecule Damage -- 9. Assessing Age-Related Changes in Antioxidant Status: The FRASC Assay for Total Antioxidant Power and Ascorbic Acid Concentration in Biological Fluids / Iris F.F. Benzie and John J. Strain -- 10. Measurement of DNA Damage and Repair Capacity as a Function of Age Using the Comet Assay / Peter H. Clingen, Jillian E. Lowe and Michael H.L. Green -- 11. Measurement of DNA Damage and Repair in Human White Blood Cells by an Immunochemical Assay / Govert P. van der Schans -- pt. IV. Age-Related Changes to Cellular Biomolecules -- 12. Measurement of 8-Oxo-deoxyguanosine in Lymphocytes, Cultured Cells, and Tissue Samples by HPLC with Electrochemical Detection / Sharon G. Wood, Catherine M. Gedik and Nicholas J. Vaughan / [et al.] -- 13. Mutation and the Aging Process: Mutant Frequency at the HPRT Gene Locus as a Function of Age in Humans / Yvonne A. Barnett and Christopher R. Barnett --".
catalog tableOfContents "[et al.] -- pt. VI. Immune System and Aging -- 21. Assessment of T-Cell Function in the Aged: T-Cell Proliferative and T-Cell Adherence Assays / Ian Beckman -- 22. Dendritic Cells in Old Age / Beatrix Grubeck-Loebenstein, Maria Saurwein-Teissl and Nikolaus Romani -- 23. Age-Related Alterations to Natural Killer Cell Function / Erminia Mariani, Corona Alonso and Rafael Solana -- 24. Immunogenetics and Life-Span: HLA / Derek Middleton, Martin D. Curran and Fionnuala Williams -- pt. VII. Case Studies -- 25. Dietary Restriction and Life-Span Extension / Byung Pal Yu -- 26. Use of Genetically Engineered Mice in Aging Research / Julie K. Andersen.".
catalog title "Aging methods and protocols / edited by Yvonne A. Barnett, Christopher R. Barnett.".
catalog type "Handbooks, manuals, etc. fast".
catalog type "Laboratory Manuals".
catalog type "text".