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• catalog abstract "Elastic filaments refer mainly to titin, the largest of all known proteins. Titin was discovered initially in muscle cells, where it interconnects the thick filament with the Z-line. Titin forms a molecular spring that is responsible for maintaining the structural integrity of contracting muscle, ensuring efficient muscle contraction. More recently, it has become clear that titin is not restricted to muscle cells alone. For example, titin is found in chromosomes of neurons and also in blood platelets. This topic is fast becoming a focal point for research in understanding viscoelastic properties at the molecular, cellular, and tissue levels. In titin may lie a generic basis for biological viscoelasticity. It has become clear that titin may hold the key to certain clinical anomalies. For example, it is clear that titin-based ventricular stiffness is modulated by calcium and that titin is responsible for the altered stiffness in cardiomyopathies. It is also clear from evidence from a group of Finnish families that titin mutations may underlie some muscular dystrophies and that with other mutations chromatids fail to separate during mitosis. Thus, it is clear that this protein will have important clinical implications stemming from its biomechanical role. One aspect of this field is the bringing together of bioengineers with clinical researchers and biologists. Genetic and biochemical aspects of titin-related proteins are being studied together with front-line engineering approaches designed to measure the mechanics of titin either in small aggregates or in single molecules.".
• catalog contributor b11829162.
• catalog contributor b11829163.
• catalog contributor b11829164.
• catalog created "c2000.".
• catalog date "2000".
• catalog date "c2000.".
• catalog dateCopyrighted "c2000.".
• catalog description "Elastic filaments refer mainly to titin, the largest of all known proteins. Titin was discovered initially in muscle cells, where it interconnects the thick filament with the Z-line. Titin forms a molecular spring that is responsible for maintaining the structural integrity of contracting muscle, ensuring efficient muscle contraction. More recently, it has become clear that titin is not restricted to muscle cells alone. For example, titin is found in chromosomes of neurons and also in blood platelets. This topic is fast becoming a focal point for research in understanding viscoelastic properties at the molecular, cellular, and tissue levels. In titin may lie a generic basis for biological viscoelasticity. It has become clear that titin may hold the key to certain clinical anomalies. For example, it is clear that titin-based ventricular stiffness is modulated by calcium and that titin is responsible for the altered stiffness in cardiomyopathies. It is also clear from evidence from a group of Finnish families that titin mutations may underlie some muscular dystrophies and that with other mutations chromatids fail to separate during mitosis. Thus, it is clear that this protein will have important clinical implications stemming from its biomechanical role. One aspect of this field is the bringing together of bioengineers with clinical researchers and biologists. Genetic and biochemical aspects of titin-related proteins are being studied together with front-line engineering approaches designed to measure the mechanics of titin either in small aggregates or in single molecules.".
• catalog description "Includes bibliographical references and index.".
• catalog description "Is titin the length sensor in cardiac muscle? Physiological and physiopathological perspectives / Jean-Yves Le Guennec -- Ca2+-dependence of passive properties of cardiac sarcomeres / Bruno D. Stuyvers -- Possible contribution of titin filaments to the compliant series elastic component in horseshoe crab skeletal muscle fibers / Haruo Sugi -- Skeletal muscle-specific calpain, p94, and connectin/titin: their physiological functions and relationship to limb-girdle muscular dystrophy type 2A / Hiroyuki Sorimachi -- From connecting filaments to co-expression of titin isoforms / Károly Trombitás.".
• catalog description "Pt. 1. Elastic filaments of the cell -- Connecting filaments: a historical perspective / Károly Tromnitás -- Connectin: from regular to giant sizes of sarcomeres / Koscak Maruyama -- Molecular tools for the study of titin's differential expression / Thomas Centner -- Sequence and mechanical implications of titin's PEVK region / Marion L. Greaser -- Probing the funcitonal roles of titan ligands in cardiac myofibril assembly and maintenance / Abigail S. McElhinny -- Assembly of myofibrils in cardiac muscle cells / Joseph W. Sanger -- pt. 2. Moleular mechanisms of elasticity -- Mechanical manipulation of single titan molecules with laser tweezers / Miklós S.Z. Kellermayer -- Unfolding forces of titin and fibronectin domains directly measured by AFM / Matthias Rief -- Computer modeling of force-induced titin domain unfolding / Hui Lu -- Extensibility in the titin molecule and its relation to muscle elasticity / Larissa Tskhovrebova -- ".
• catalog description "Titin elasticity in the context of the sarcomere: force and extensibility measurements on single myofibrils / Wolfgang A. Linke -- pt. 3. Titin-like proteins -- Links in the chain: the contribution of kettin to the elasticity of insect muscles / Belinda Bullard -- Titin as a chromosomal protein / Cristina Machado -- Role of elastic protein projectin in stretch activation and work output of Drosophila flight muscles / Jim O. Vigoreaux -- Drosophila projectin: a look at protein structure and sarcomeric assembly / Agnes Ayme-Southgate -- Role of titin in nonmuscle and smooth muscle cells / Thomas C.S. Keller, III -- pt. 4. Functional role of elastic filaments -- Mechanical properties of titin isoforms / Henk Granzier -- Intact connecting filaments change length in 2.3-nm quanta / Felix Blyakham -- Titin-thin filament interaction and potential role in muscle function / Jian-Ping Jin -- ".
• catalog extent "ix, 425 p. :".
• catalog identifier "0306464101".
• catalog isPartOf "Advances in experimental medicine and biology ; v. 481".
• catalog issued "2000".
• catalog issued "c2000.".
• catalog language "eng".
• catalog publisher "New York : Kluwer Academic / Plenum Publishers,".
• catalog subject "571.6/5 21".
• catalog subject "Cytoplasmic filaments Congresses.".
• catalog subject "Cytoskeleton Congresses.".
• catalog subject "Cytoskeleton".
• catalog subject "Intermediate Filament Proteins Congresses.".
• catalog subject "Intermediate Filament Proteins".
• catalog subject "Intermediate filament proteins Congresses.".
• catalog subject "Muscle Contraction Congresses.".
• catalog subject "Muscle Contraction".
• catalog subject "Muscle contraction Congresses.".
• catalog subject "Muscles cytology".
• catalog subject "Myofibrils Congresses.".
• catalog subject "Myofibroblasts Congresses.".
• catalog subject "QH603.C95 E43 2000".
• catalog subject "W1 AD559 v.481 2000".
• catalog subject "WE 500 E37 2000".
• catalog tableOfContents "Is titin the length sensor in cardiac muscle? Physiological and physiopathological perspectives / Jean-Yves Le Guennec -- Ca2+-dependence of passive properties of cardiac sarcomeres / Bruno D. Stuyvers -- Possible contribution of titin filaments to the compliant series elastic component in horseshoe crab skeletal muscle fibers / Haruo Sugi -- Skeletal muscle-specific calpain, p94, and connectin/titin: their physiological functions and relationship to limb-girdle muscular dystrophy type 2A / Hiroyuki Sorimachi -- From connecting filaments to co-expression of titin isoforms / Károly Trombitás.".
• catalog tableOfContents "Pt. 1. Elastic filaments of the cell -- Connecting filaments: a historical perspective / Károly Tromnitás -- Connectin: from regular to giant sizes of sarcomeres / Koscak Maruyama -- Molecular tools for the study of titin's differential expression / Thomas Centner -- Sequence and mechanical implications of titin's PEVK region / Marion L. Greaser -- Probing the funcitonal roles of titan ligands in cardiac myofibril assembly and maintenance / Abigail S. McElhinny -- Assembly of myofibrils in cardiac muscle cells / Joseph W. Sanger -- pt. 2. Moleular mechanisms of elasticity -- Mechanical manipulation of single titan molecules with laser tweezers / Miklós S.Z. Kellermayer -- Unfolding forces of titin and fibronectin domains directly measured by AFM / Matthias Rief -- Computer modeling of force-induced titin domain unfolding / Hui Lu -- Extensibility in the titin molecule and its relation to muscle elasticity / Larissa Tskhovrebova -- ".
• catalog tableOfContents "Titin elasticity in the context of the sarcomere: force and extensibility measurements on single myofibrils / Wolfgang A. Linke -- pt. 3. Titin-like proteins -- Links in the chain: the contribution of kettin to the elasticity of insect muscles / Belinda Bullard -- Titin as a chromosomal protein / Cristina Machado -- Role of elastic protein projectin in stretch activation and work output of Drosophila flight muscles / Jim O. Vigoreaux -- Drosophila projectin: a look at protein structure and sarcomeric assembly / Agnes Ayme-Southgate -- Role of titin in nonmuscle and smooth muscle cells / Thomas C.S. Keller, III -- pt. 4. Functional role of elastic filaments -- Mechanical properties of titin isoforms / Henk Granzier -- Intact connecting filaments change length in 2.3-nm quanta / Felix Blyakham -- Titin-thin filament interaction and potential role in muscle function / Jian-Ping Jin -- ".
• catalog title "Elastic filaments of the cell / edited by Henk L. Granzier and Gerald H. Pollack.".
• catalog type "Conference proceedings. fast".
• catalog type "Congresses".
• catalog type "text".