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catalog alternative "PNH and the GPI-linked proteins".
catalog contributor b11838461.
catalog contributor b11838462.
catalog created "c2000.".
catalog date "2000".
catalog date "c2000.".
catalog dateCopyrighted "c2000.".
catalog description "Chimeric Mice Bearing PIGA(-) Hematopoietic Stem -- Cells 149 -- Hematopoiesis by Cells from Patients with PNH in SCID -- Mice 154 -- Conclusions and Perspectives 155 -- References 155 -- 7 -- The Function of GPI-Anchored Proteins -- Ian Okazaki and Joel Moss -- Introduction 159 -- GPI-Linked Proteins and Cell Signaling 161 -- Role of GPI-Anchored Proteins in Insulin Action 166 -- GPI-Anchored Proteins Function as Receptors 166 -- GPI Anchors and Membrane Structure 168 -- Summary 170 -- References 171 -- 8 -- GPI in Lower Animals -- Louis Schofield -- Introduction 179 -- Structures of Protozoal GPIs 180 -- Evidence for GPI-Mediated Signaling in Mammalian Cell -- Biology 182 -- Signal Transduction in Host Cells by Protozoal -- GPIs 185 -- Parasite GPIs as Functional Toxins and Pathogenicity -- Factors 187 -- Regulation of Macrophage Function by Glycoconjugates of -- Leishmania 188 -- Regulation of Host Cells by Ceramide-Containing GPIs of -- T. cruzi 189 -- ".
catalog description "Includes bibliographical references and index.".
catalog description "Insulin-Mimetic Activities of Protozoal GPIs 189 -- CD1d-Restricted NK T Cells and Immunity to GPI-Anchored -- Proteins 190 -- Conclusions 191 -- References 192 -- 9 -- Synthesis of the GPI Anchor -- Daniel Sevlever, Rui Chen, and M. Edward Medof -- Introduction 199 -- GPI Biosynthetic Pathway 200 -- Mammalian and Yeast GPI-Anchor Defective -- Mutants 203 -- GPI-Anchor Addition to Proteins 207 -- Biological Implications of GPI Anchoring 210 -- Conclusions 213 -- References 214 -- 10 -- Functional and Structural Organization -- of GPI-Anchored Proteins in -- Cellular Membranes -- Satyajit Mayor -- Introduction 221 -- GPI-Anchor Function and the "Raft" Hypothesis 221 -- Lateral Heterogeneity in Cell Membranes 222 -- Detergent-Resistant Membranes and Their Connection with -- Rafts 223 -- Evidence for Rafts in Living Cell Membranes 227 -- Involvement of Rafts in Biosynthetic and Endocytic -- Sorting 230 -- Rafts and Signaling by GPIAPs 232 -- In Conclusion 233 -- References 233 -- 11 -- ".
catalog description "Machine generated contents note: 1 -- A Brief History of PNH -- Wendell Rosse -- The Diagnosis of PNH 8 -- Summary 15 -- References 16 -- 2 -- Genetics of PNH -- Lucio Luzzatto and Khedoudja Nafa -- Biochemical Genetics of PNH in Somatic Cells 21 -- The PIG-A Gene 23 -- The PIG-A Protein 24 -- Detecting Mutations in the PIG-A Gene 27 -- Germ Line PIG-A Mutations 32 -- The Spectrum of Somatic Mutations in the PIG-A -- Gene 33 -- PIG-A Mutations without PNH 40 -- Structure-Function Relationships 41 -- Correlation between Phenotypes and Genotypes 42 -- Comparison of the Spectrum of Mutations in Three X-Linked -- Genes: PIG-A, FVIII, and G6PD 42 -- Conclusion 43 -- References 44 -- 3 -- Hemolysis in PNH -- Charles J. Parker -- Introduction 49 -- The Classical Pathway of Complement 55 -- The Alternative Pathway of Complement 61 -- Phenotypic Mosaicism 64 -- Functional Basis of the Abnormal Sensitivity of the -- Erythrocytes of PNH to Complement-Mediated -- Lysis 68 -- ".
catalog description "Structure and Function of -- GPI-Specific Phospholipases -- Martin G. Low -- Introduction: GPI Anchors and Phospholipases 239 -- Biochemical Properties of Plasma GPI-PLD 245 -- Distribution of GPI-PLD in Tissues and Cells 252 -- Physiological Role of GPI-PLD 257 -- References 262.".
catalog description "Treatment of Hemolysis 83 -- Summary and Conclusions 86 -- References 89 -- 4 -- Thrombotic Complications in PNH -- Elaine M. Sloand and Neal S. Young -- Introduction 101 -- Incidence of Thrombosis in PNH 102 -- Factors Associated with Venous Thrombosis 103 -- Platelet Abnormalities in PNH 104 -- Role of Red Cell and Platelet Microvesicles 107 -- Urokinase Activator Receptor (uPAR) and Cell-Mediated -- Fibrinolysis 108 -- Treatment of Thrombosis in PNH 109 -- Summary 109 -- References 110 -- 5 -- Bone Marrow Failure in PNH -- Daniel E. Dunn, Johnson M. Liu, and Neal S. Young -- Introduction 113 -- Pathophysiology of Marrow Failure in PNH 115 -- An Immune Model of PNH Pathogenesis 120 -- Clinical Course and Treatment of Marrow Failure in -- PNH 127 -- Summary 130 -- References 131 -- 6 -- Animal Models of PNH -- Taroh Kinoshita, Monica Bessler, and Junji Takeda -- Introduction 139 -- Mouse Piga Gene 141 -- In Vitro Differentiation of PIGA(-) ES Cells 143 -- ".
catalog extent "xiii, 279 p. :".
catalog identifier "0127729402 (alk. paper)".
catalog issued "2000".
catalog issued "c2000.".
catalog language "eng".
catalog publisher "San Diego, Calif. : Academic Press,".
catalog subject "2000 E-108".
catalog subject "Cellular signal transduction.".
catalog subject "Glycoproteins.".
catalog subject "Glycosylphosphatidylinositols.".
catalog subject "Hemoglobinuria, Paroxysmal.".
catalog subject "Membrane proteins.".
catalog subject "Paroxysmal hemoglobinuria.".
catalog subject "Phosphoinositides.".
catalog subject "RC641.7.P37 P37 2000".
catalog subject "WJ 344 P257 2000".
catalog tableOfContents "Chimeric Mice Bearing PIGA(-) Hematopoietic Stem -- Cells 149 -- Hematopoiesis by Cells from Patients with PNH in SCID -- Mice 154 -- Conclusions and Perspectives 155 -- References 155 -- 7 -- The Function of GPI-Anchored Proteins -- Ian Okazaki and Joel Moss -- Introduction 159 -- GPI-Linked Proteins and Cell Signaling 161 -- Role of GPI-Anchored Proteins in Insulin Action 166 -- GPI-Anchored Proteins Function as Receptors 166 -- GPI Anchors and Membrane Structure 168 -- Summary 170 -- References 171 -- 8 -- GPI in Lower Animals -- Louis Schofield -- Introduction 179 -- Structures of Protozoal GPIs 180 -- Evidence for GPI-Mediated Signaling in Mammalian Cell -- Biology 182 -- Signal Transduction in Host Cells by Protozoal -- GPIs 185 -- Parasite GPIs as Functional Toxins and Pathogenicity -- Factors 187 -- Regulation of Macrophage Function by Glycoconjugates of -- Leishmania 188 -- Regulation of Host Cells by Ceramide-Containing GPIs of -- T. cruzi 189 -- ".
catalog tableOfContents "Insulin-Mimetic Activities of Protozoal GPIs 189 -- CD1d-Restricted NK T Cells and Immunity to GPI-Anchored -- Proteins 190 -- Conclusions 191 -- References 192 -- 9 -- Synthesis of the GPI Anchor -- Daniel Sevlever, Rui Chen, and M. Edward Medof -- Introduction 199 -- GPI Biosynthetic Pathway 200 -- Mammalian and Yeast GPI-Anchor Defective -- Mutants 203 -- GPI-Anchor Addition to Proteins 207 -- Biological Implications of GPI Anchoring 210 -- Conclusions 213 -- References 214 -- 10 -- Functional and Structural Organization -- of GPI-Anchored Proteins in -- Cellular Membranes -- Satyajit Mayor -- Introduction 221 -- GPI-Anchor Function and the "Raft" Hypothesis 221 -- Lateral Heterogeneity in Cell Membranes 222 -- Detergent-Resistant Membranes and Their Connection with -- Rafts 223 -- Evidence for Rafts in Living Cell Membranes 227 -- Involvement of Rafts in Biosynthetic and Endocytic -- Sorting 230 -- Rafts and Signaling by GPIAPs 232 -- In Conclusion 233 -- References 233 -- 11 -- ".
catalog tableOfContents "Machine generated contents note: 1 -- A Brief History of PNH -- Wendell Rosse -- The Diagnosis of PNH 8 -- Summary 15 -- References 16 -- 2 -- Genetics of PNH -- Lucio Luzzatto and Khedoudja Nafa -- Biochemical Genetics of PNH in Somatic Cells 21 -- The PIG-A Gene 23 -- The PIG-A Protein 24 -- Detecting Mutations in the PIG-A Gene 27 -- Germ Line PIG-A Mutations 32 -- The Spectrum of Somatic Mutations in the PIG-A -- Gene 33 -- PIG-A Mutations without PNH 40 -- Structure-Function Relationships 41 -- Correlation between Phenotypes and Genotypes 42 -- Comparison of the Spectrum of Mutations in Three X-Linked -- Genes: PIG-A, FVIII, and G6PD 42 -- Conclusion 43 -- References 44 -- 3 -- Hemolysis in PNH -- Charles J. Parker -- Introduction 49 -- The Classical Pathway of Complement 55 -- The Alternative Pathway of Complement 61 -- Phenotypic Mosaicism 64 -- Functional Basis of the Abnormal Sensitivity of the -- Erythrocytes of PNH to Complement-Mediated -- Lysis 68 -- ".
catalog tableOfContents "Structure and Function of -- GPI-Specific Phospholipases -- Martin G. Low -- Introduction: GPI Anchors and Phospholipases 239 -- Biochemical Properties of Plasma GPI-PLD 245 -- Distribution of GPI-PLD in Tissues and Cells 252 -- Physiological Role of GPI-PLD 257 -- References 262.".
catalog tableOfContents "Treatment of Hemolysis 83 -- Summary and Conclusions 86 -- References 89 -- 4 -- Thrombotic Complications in PNH -- Elaine M. Sloand and Neal S. Young -- Introduction 101 -- Incidence of Thrombosis in PNH 102 -- Factors Associated with Venous Thrombosis 103 -- Platelet Abnormalities in PNH 104 -- Role of Red Cell and Platelet Microvesicles 107 -- Urokinase Activator Receptor (uPAR) and Cell-Mediated -- Fibrinolysis 108 -- Treatment of Thrombosis in PNH 109 -- Summary 109 -- References 110 -- 5 -- Bone Marrow Failure in PNH -- Daniel E. Dunn, Johnson M. Liu, and Neal S. Young -- Introduction 113 -- Pathophysiology of Marrow Failure in PNH 115 -- An Immune Model of PNH Pathogenesis 120 -- Clinical Course and Treatment of Marrow Failure in -- PNH 127 -- Summary 130 -- References 131 -- 6 -- Animal Models of PNH -- Taroh Kinoshita, Monica Bessler, and Junji Takeda -- Introduction 139 -- Mouse Piga Gene 141 -- In Vitro Differentiation of PIGA(-) ES Cells 143 -- ".
catalog title "PNH and the GPI-linked proteins".
catalog title "Paroxysmal nocturnal hemoglobinuria and the glycosylphosphatidylinositol-linked proteins / edited by Neal S. Young, Joel Moss.".
catalog type "text".