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- catalog abstract "Advances in biochemistry, cell biology, genome-wide mutagenesis -- coupled with molecular technology, including gene microarray and transgenic and knock-out animals -- have been instrumental in understanding the cellular processes and molecular pathways of self-tolerance and autoimmune diseases. The molecular definition of these pathways and processes has led to novel treatments for certain auto-immune diseases that are based on the pathogenesis of diseases rather than on broad-spectrum immunosuppression. This book reviews many of these current developments and proposes future novel approaches for understanding the pathogenesis of auto-immune diseases and designing novel therapy. This book covers three major areas of auto-immunity: the basic mechanisms of immunological tolerance, pathogenesis of auto-immune diseases, and some novel therapies.".
- catalog alternative "Autoimmunity 2000 and beyond".
- catalog contributor b12245936.
- catalog created "c2001.".
- catalog date "2001".
- catalog date "c2001.".
- catalog dateCopyrighted "c2001.".
- catalog description "1. Basic mechanisms -- Delineation of the pathogenesis of systemic lupus erythematosus by using murine models -- Factors contributing to autoimmune disease -- Control of autoimmunity by regulatory T cells -- Autoimmunity, self-tolerance, and immune homeostasis: from whole animal phenotypes to molecular pathways -- Peripheral tolerance and organ specific autoimmunity -- Autoimmune lymphoproliferative syndrome: types I, II, and beyond -- 2. Pathogenesis -- The role of MHC class II molecules in the pathogenesis and prevention of type I diabetes -- Control of autoreactive T cell activation by immuoregulatory T cells -- Immune tolerance and the nervous system -- Functional role of epitope spreading in the chronic pathogenesis of autoimmune and virus-induced demyelinating diseases -- 3. Therapy -- Multiple sclerosis and gene expesssion profiling -- Treatment of autoimmuity by inhibition of T cell costimulation -- Cytokine blockade in rheumatoid arthritis.".
- catalog description "Advances in biochemistry, cell biology, genome-wide mutagenesis -- coupled with molecular technology, including gene microarray and transgenic and knock-out animals -- have been instrumental in understanding the cellular processes and molecular pathways of self-tolerance and autoimmune diseases. The molecular definition of these pathways and processes has led to novel treatments for certain auto-immune diseases that are based on the pathogenesis of diseases rather than on broad-spectrum immunosuppression. This book reviews many of these current developments and proposes future novel approaches for understanding the pathogenesis of auto-immune diseases and designing novel therapy. This book covers three major areas of auto-immunity: the basic mechanisms of immunological tolerance, pathogenesis of auto-immune diseases, and some novel therapies.".
- catalog description "Includes bibliographical references and index.".
- catalog extent "viii, 136 p. :".
- catalog identifier "0306465701".
- catalog isPartOf "Advances in experimental medicine and biology ; v. 490".
- catalog issued "2001".
- catalog issued "c2001.".
- catalog language "eng".
- catalog publisher "New York : Kluwer Academic/Plenum,".
- catalog subject "Autoimmune Diseases therapy.".
- catalog subject "Autoimmune diseases Pathogenesis.".
- catalog subject "Autoimmunity.".
- catalog subject "Lymphocyte Activation".
- catalog subject "Lymphocytes immunology.".
- catalog subject "QR188.3 .M43 2001".
- catalog subject "QW 545 M486 2001".
- catalog subject "W1 AD559 v.490 2001".
- catalog tableOfContents "1. Basic mechanisms -- Delineation of the pathogenesis of systemic lupus erythematosus by using murine models -- Factors contributing to autoimmune disease -- Control of autoimmunity by regulatory T cells -- Autoimmunity, self-tolerance, and immune homeostasis: from whole animal phenotypes to molecular pathways -- Peripheral tolerance and organ specific autoimmunity -- Autoimmune lymphoproliferative syndrome: types I, II, and beyond -- 2. Pathogenesis -- The role of MHC class II molecules in the pathogenesis and prevention of type I diabetes -- Control of autoreactive T cell activation by immuoregulatory T cells -- Immune tolerance and the nervous system -- Functional role of epitope spreading in the chronic pathogenesis of autoimmune and virus-induced demyelinating diseases -- 3. Therapy -- Multiple sclerosis and gene expesssion profiling -- Treatment of autoimmuity by inhibition of T cell costimulation -- Cytokine blockade in rheumatoid arthritis.".
- catalog title "Autoimmunity 2000 and beyond".
- catalog title "Mechanisms of lymphocyte activation and immune regulation VIII : autoimmunity 2000 and beyond / edited by Sudhir Gupta.".
- catalog type "text".