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catalog abstract ""The [beta][subscript 3]-Adrenoreceptor covers all the latest developments in the field. It begins with a general overview of the structure, function and expression of the [beta][subscript 3]AR, before discussing regulation of the receptor and the consequences of [beta][subscript 3]AR gene knockout. A detailed description of the receptor's pharmacology and functional role in humans is also given, followed by an account of its lesser-known vasodilatory role. Finally the biology of brown adipose tissue is described, in which the [beta][subscript 3]AR plays a crucial functional role. Throughout, the [beta][subscript 3]AR is placed in context by reference to [beta][subscript 1]AR and [beta][subscript 2]AR homologues as well as the more recently described, still putative, fourth [beta]AR." "Suitable for researchers from industry and academia, this timely book presents a clear and complete description of the [beta][subscript 3]AR, with contributions from many of those involved in [beta][subscript 3]AR research from the very beginning."--Jacket.".
catalog alternative "Beta 3 adrenoreceptor".
catalog contributor b12340607.
catalog created "2000.".
catalog date "2000".
catalog date "2000.".
catalog dateCopyrighted "2000.".
catalog description ""The [beta][subscript 3]-Adrenoreceptor covers all the latest developments in the field. It begins with a general overview of the structure, function and expression of the [beta][subscript 3]AR, before discussing regulation of the receptor and the consequences of [beta][subscript 3]AR gene knockout. A detailed description of the receptor's pharmacology and functional role in humans is also given, followed by an account of its lesser-known vasodilatory role. Finally the biology of brown adipose tissue is described, in which the [beta][subscript 3]AR plays a crucial functional role.".
catalog description "1 Structure and Function of the [beta subscript 3]-Adrenoreceptor / A. Donny Strosberg, Cindy C. Gerhardt 1 -- 1.2 [Beta subscript 3]AR gene 2 -- 1.2.1 Cloning of the gene 2 -- 1.2.2 Structure of the coding region 3 -- 1.2.3 Structure of the promoter 3 -- 1.3 [Beta subscript 3]AR protein 4 -- 1.3.1 Comparison with [beta subscript 1]- and [beta subscript 2]AR 4 -- 1.3.2 Comparison of [beta subscript 3]AR from various species 7 -- 1.3.3 Polymorphism 9 -- 1.4 Structure--function relationships in the [beta subscript 3]AR 10 -- 1.4.1 Ligand binding site 10 -- 1.4.2 Regions of interaction with the G proteins 11 -- 1.5 Signal transduction and biological functions 12 -- 1.5.1 [beta subscript 3]AR-mediated activation of adenylyl cyclase 12 -- 1.5.2 [beta subscript 3]AR-mediated activation of other signalling pathways 14 -- 1.5.3 A role for the [beta subscript 3]AR in adipocyte differentiation".
catalog description "15 -- 1.6 Distribution of the [beta subscript 3]AR 15 -- 1.6.1 Functional detection of the [beta subscript 3]AR 16 -- 1.6.2 Immunodetection of the [beta subscript 3]AR protein 17 -- 1.6.3 Detection of the [beta subscript 3]AR mRNA 18 -- 2 Regulation of the [beta subscript 3]-Adrenoreceptor Signalling Efficacy / Michel Bouvier 20 -- 2.1.1 [Beta]-adrenoreceptors and their signalling pathways 21 -- 2.2 General concepts of G protein-coupled signalling regulation 22 -- 2.2.1 Agonist-promoted receptor phosphorylation and receptor uncoupling 22 -- 2.2.2 Receptor sequestration; a process involved in desensitization and resensitization 24 -- 2.2.3 Agonist-promoted down-regulation 26 -- 2.3 [Beta subscript 3]-adrenoreceptor, a prototypic system to study subtype-specific regulation 27 -- 2.3.1 Comparative analysis of the structural determinants of receptor regulation 27 -- 2.4".
catalog description "3.3 Role of [beta subscript 3]AR on white versus brown adipocytes in mediating effects of [beta subscript 3]-selective agonists on energy expenditure, insulin secretion and food intake 40 -- 3.3.1 Role of white versus brown adipocyte [beta subscript 3]AR in mediating effects of CL-316,243 on energy expenditure 41 -- 3.3.2 Role of white versus brown adipocyte [beta subscript 3]AR in mediating effects of CL-316,243 on insulin secretion 42 -- 3.3.3 Role of white versus brown adipocyte [beta subscript 3]AR in mediating effects of CL-316,243 on food intake 42 -- 3.4 Creation of mice which express human, but not murine, [beta subscript 3]AR 43 -- 3.5 Using [beta subscript 3]AR gene knockout mice to study '[beta subscript 4]AR' activity 46 -- 3.5.1 Evidence for the existence of '[beta subscript 4]AR' 46 -- 3.5.2 Assessment of '[beta subscript 4]AR' activity in [beta subscript 3]AR gene knockout mice 47 -- 4".
catalog description "93 -- 6.4.1 Regulation of pancreatic islet blood flow 93 -- 6.4.2 Regulation of gastric mucosal blood flow 95 -- 6.5 [beta subscript 3]AR-mediated cardiovascular effects 95 -- 7 [beta subscript 3]-Adrenoreceptors in Brown and White Adipocytes: Roles in Thermogenesis and Energy Balance / Jean Himms-Hagen 97 -- 7.2 Brown and white adipocytes and tissues 98 -- 7.2.1 Functions of brown and white adipocytes 98 -- 7.2.2 Definition and tissue distribution of brown and white adipocytes 99 -- 7.2.3 Definition of BAT and WAT 101 -- 7.2.4 Multiple UCPs in BAT 101 -- 7.2.5 Adrenoreceptors in brown adipocytes 102 -- 7.2.6 Control of brown adipocytes by the sympathetic nervous system and the hypothalamus 103 -- 7.2.7 Central and peripheral effects of insulin in maintenance of thermogenic capacity of BAT 104 -- 7.2.8 Control of blood flow in BAT by the sympathetic nervous system and the hypothalamus 105 -- 7.3".
catalog description "Human [beta subscript 3]AR gene 77 -- 5.3 Tissue expression of mRNA for [beta subscript 3]AR 78 -- 5.3.1 White adipose tissue 78 -- 5.3.2 Brown adipose tissue 80 -- 5.3.3 Heart 81 -- 5.3.4 Colon 81 -- 5.3.5 Brain 81 -- 5.3.6 Urinary bladder 81 -- 5.3.7 Other tissues 82 -- 5.4 Is there a fourth [beta]AR? 82 -- 5.5 Structural variations in the native human [beta subscript 3]AR 83 -- 5.6 [beta subscript 3]AR as a therapeutic target 84 -- 6 [beta subscript 3]-Adrenoreceptor-Mediated Responses in Heart and Vessels / Max Lafontan, Dominique Langin, Jean Galitzky, Michel Berlan, Chantal Gauthier, Genevieve Tavernier 87 -- 6.2 [beta]AR subtypes in the heart 87 -- 6.2.1 Functional [beta subscript 3]AR in the human heart 88 -- 6.2.2 Putative [beta subscript 4]AR in cardiac tissue 90 -- 6.3 [beta subscript 3]AR-mediated vasodilatation 91 -- 6.4 [beta subscript 3]AR regulation of blood flow".
catalog description "Includes bibliographical references (p. 125-166) and index.".
catalog description "Origin of brown adipocytes 105 -- 7.3.1 Differentiation of brown adipocytes and mitochondriogenesis 105 -- 7.3.2 Induction of hyperplasia of brown adipocytes in BAT 108 -- 7.3.3 Expression of multiple UCPs in brown adipocytes: function and regulation 109 -- 7.3.4 Induction of emergence of 'ectopic' brown adipocytes in WAT 109 -- 7.3.5 Is there more than one type of brown adipocyte? 110 -- 7.4 Physiological functions of brown adipose tissue 112 -- 7.4.1 Role in thermoregulation in a cold environment 112 -- 7.4.2 Role in food intake 113 -- 7.4.3 Role in defence against obesity 113 -- 7.5 Secretions from brown adipocytes 115 -- 7.5.1 Satiety factors 115 -- 7.5.2 Other factors 116 -- 7.6 [beta subscript 3]ARs in brown and white adipocytes as a target for anti-obesity and anti-diabetes drugs 117 -- 7.7 Perspective 119 -- 8".
catalog description "Putative '[beta subscript 4]'-Adrenoreceptor and Other Atypical [beta]-Adrenoreceptors / A. Donny Strosberg, Jonathan R.S. Arch 120 -- 8.2 Pharmacology of the [beta subscript 4]AR and other atypical [beta]ARs 120 -- 8.3 A summary of '[beta subscript 4]'AR pharmacology 121 -- 8.4 Search for molecular evidence for atypical [beta]ARs 123 -- 8.4.1 Discovery of the [beta subscript 3]AR gene and other putative homologues 123 -- 8.4.2 Discovery of a receptor which binds iodocyanopindolol and other3 [beta subscript 3]AR ligands 123 -- 8.4.3 Non-[beta subscript 3]AR-like pharmacological properties of [beta subscript 3]AR proteins 123.".
catalog description "Throughout, the [beta][subscript 3]AR is placed in context by reference to [beta][subscript 1]AR and [beta][subscript 2]AR homologues as well as the more recently described, still putative, fourth [beta]AR." "Suitable for researchers from industry and academia, this timely book presents a clear and complete description of the [beta][subscript 3]AR, with contributions from many of those involved in [beta][subscript 3]AR research from the very beginning."--Jacket.".
catalog description "[Beta subscript 3]-adrenoreceptor is resistant to rapid agonist-promoted uncoupling and sequestration 29 -- 2.5 Cell type-specific down-regulation of the [beta subscript 3]-adrenoreceptor 30 -- 2.6 Use of chimeric [beta subscript 3]/[beta subscript 2]-adrenoreceptors to delineate regulatory motifs 33 -- 2.7 Potential physiological consequences of the relative resistance of the [beta subscript 3]-adrenoreceptor to desensitization 34 -- 3 Using Transgenic and Gene Knockout Techniques to Assess [beta subscript 3]-Adrenoreceptor Function / Bradford B. Lowell, Vedrana S. Susulic, Danica Grujic, Moriko Ito 36 -- 3.2 Mice lacking [beta subscript 3]AR 36 -- 3.2.1 Phenotype of mice lacking [beta subscript 3]AR 36 -- 3.2.2 Effects of [beta subscript 3]AR deficiency on catecholamine-mediated stimulation of adenylyl cyclase and lipolysis in adipocytes 38 -- 3.2.3 Effects of [beta subscript 3]AR deficiency on in vivo effects of CL-316,243 40 --".
catalog description "[beta subscript 3]-Adrenoreceptor Ligands and the Pharmacology of the [beta subscript 3]-Adrenoreceptor / Jonathan R.S. Arch 48 -- 4.2 Antagonists 49 -- 4.2.1 [beta subscript 1/2]AR-selective antagonists 49 --3 4.2.2 Non-selective and [beta subscript 3]AR-selective antagonists 52 -- 4.3 Agonists 55 -- 4.3.1 [beta subscript 1/2]AR-selective agonists 55 -- 4.3.2 Arylethanolamine [beta subscript 3]AR-selective agonists 55 -- 4.3.3 Aryloxypropanolamine [beta subscript 3]AR agonists 66 -- 4.3.4 Trimetoquinol and analogues 72 -- 4.3.5 Metabolism and pharmacokinetics 73 -- 4.4 Idiosyncrasies of [beta subscript 3]AR pharmacology 74 -- 4.4.1 Relative agonist potencies vary with the nature of the assay 74 -- 4.4.2 Prediction of human tissue pharmacology from cloned receptor pharmacology 75 -- 5 Native Human [beta subscript 3]-Adrenoreceptor / Peter Arner, Fredrik Lonnqvist 77 -- 5.2".
catalog extent "xviii, 170 p. :".
catalog identifier "0748408045".
catalog isPartOf "Taylor & Francis series in pharmaceutical sciences".
catalog issued "2000".
catalog issued "2000.".
catalog language "eng".
catalog publisher "London ; New York : Taylor & Francis,".
catalog subject "2001 A-631".
catalog subject "612/.01575 21".
catalog subject "Adrenergic beta agonists.".
catalog subject "Adrenergic beta-Agonists.".
catalog subject "Beta adrenoceptors.".
catalog subject "QP364.7 .B13 2000".
catalog subject "Receptors, Adrenergic, beta-3 genetics.".
catalog subject "Receptors, Adrenergic, beta-3 physiology.".
catalog subject "WL 102.8 B5627 2000".
catalog tableOfContents "1 Structure and Function of the [beta subscript 3]-Adrenoreceptor / A. Donny Strosberg, Cindy C. Gerhardt 1 -- 1.2 [Beta subscript 3]AR gene 2 -- 1.2.1 Cloning of the gene 2 -- 1.2.2 Structure of the coding region 3 -- 1.2.3 Structure of the promoter 3 -- 1.3 [Beta subscript 3]AR protein 4 -- 1.3.1 Comparison with [beta subscript 1]- and [beta subscript 2]AR 4 -- 1.3.2 Comparison of [beta subscript 3]AR from various species 7 -- 1.3.3 Polymorphism 9 -- 1.4 Structure--function relationships in the [beta subscript 3]AR 10 -- 1.4.1 Ligand binding site 10 -- 1.4.2 Regions of interaction with the G proteins 11 -- 1.5 Signal transduction and biological functions 12 -- 1.5.1 [beta subscript 3]AR-mediated activation of adenylyl cyclase 12 -- 1.5.2 [beta subscript 3]AR-mediated activation of other signalling pathways 14 -- 1.5.3 A role for the [beta subscript 3]AR in adipocyte differentiation".
catalog tableOfContents "15 -- 1.6 Distribution of the [beta subscript 3]AR 15 -- 1.6.1 Functional detection of the [beta subscript 3]AR 16 -- 1.6.2 Immunodetection of the [beta subscript 3]AR protein 17 -- 1.6.3 Detection of the [beta subscript 3]AR mRNA 18 -- 2 Regulation of the [beta subscript 3]-Adrenoreceptor Signalling Efficacy / Michel Bouvier 20 -- 2.1.1 [Beta]-adrenoreceptors and their signalling pathways 21 -- 2.2 General concepts of G protein-coupled signalling regulation 22 -- 2.2.1 Agonist-promoted receptor phosphorylation and receptor uncoupling 22 -- 2.2.2 Receptor sequestration; a process involved in desensitization and resensitization 24 -- 2.2.3 Agonist-promoted down-regulation 26 -- 2.3 [Beta subscript 3]-adrenoreceptor, a prototypic system to study subtype-specific regulation 27 -- 2.3.1 Comparative analysis of the structural determinants of receptor regulation 27 -- 2.4".
catalog tableOfContents "3.3 Role of [beta subscript 3]AR on white versus brown adipocytes in mediating effects of [beta subscript 3]-selective agonists on energy expenditure, insulin secretion and food intake 40 -- 3.3.1 Role of white versus brown adipocyte [beta subscript 3]AR in mediating effects of CL-316,243 on energy expenditure 41 -- 3.3.2 Role of white versus brown adipocyte [beta subscript 3]AR in mediating effects of CL-316,243 on insulin secretion 42 -- 3.3.3 Role of white versus brown adipocyte [beta subscript 3]AR in mediating effects of CL-316,243 on food intake 42 -- 3.4 Creation of mice which express human, but not murine, [beta subscript 3]AR 43 -- 3.5 Using [beta subscript 3]AR gene knockout mice to study '[beta subscript 4]AR' activity 46 -- 3.5.1 Evidence for the existence of '[beta subscript 4]AR' 46 -- 3.5.2 Assessment of '[beta subscript 4]AR' activity in [beta subscript 3]AR gene knockout mice 47 -- 4".
catalog tableOfContents "93 -- 6.4.1 Regulation of pancreatic islet blood flow 93 -- 6.4.2 Regulation of gastric mucosal blood flow 95 -- 6.5 [beta subscript 3]AR-mediated cardiovascular effects 95 -- 7 [beta subscript 3]-Adrenoreceptors in Brown and White Adipocytes: Roles in Thermogenesis and Energy Balance / Jean Himms-Hagen 97 -- 7.2 Brown and white adipocytes and tissues 98 -- 7.2.1 Functions of brown and white adipocytes 98 -- 7.2.2 Definition and tissue distribution of brown and white adipocytes 99 -- 7.2.3 Definition of BAT and WAT 101 -- 7.2.4 Multiple UCPs in BAT 101 -- 7.2.5 Adrenoreceptors in brown adipocytes 102 -- 7.2.6 Control of brown adipocytes by the sympathetic nervous system and the hypothalamus 103 -- 7.2.7 Central and peripheral effects of insulin in maintenance of thermogenic capacity of BAT 104 -- 7.2.8 Control of blood flow in BAT by the sympathetic nervous system and the hypothalamus 105 -- 7.3".
catalog tableOfContents "Human [beta subscript 3]AR gene 77 -- 5.3 Tissue expression of mRNA for [beta subscript 3]AR 78 -- 5.3.1 White adipose tissue 78 -- 5.3.2 Brown adipose tissue 80 -- 5.3.3 Heart 81 -- 5.3.4 Colon 81 -- 5.3.5 Brain 81 -- 5.3.6 Urinary bladder 81 -- 5.3.7 Other tissues 82 -- 5.4 Is there a fourth [beta]AR? 82 -- 5.5 Structural variations in the native human [beta subscript 3]AR 83 -- 5.6 [beta subscript 3]AR as a therapeutic target 84 -- 6 [beta subscript 3]-Adrenoreceptor-Mediated Responses in Heart and Vessels / Max Lafontan, Dominique Langin, Jean Galitzky, Michel Berlan, Chantal Gauthier, Genevieve Tavernier 87 -- 6.2 [beta]AR subtypes in the heart 87 -- 6.2.1 Functional [beta subscript 3]AR in the human heart 88 -- 6.2.2 Putative [beta subscript 4]AR in cardiac tissue 90 -- 6.3 [beta subscript 3]AR-mediated vasodilatation 91 -- 6.4 [beta subscript 3]AR regulation of blood flow".
catalog tableOfContents "Origin of brown adipocytes 105 -- 7.3.1 Differentiation of brown adipocytes and mitochondriogenesis 105 -- 7.3.2 Induction of hyperplasia of brown adipocytes in BAT 108 -- 7.3.3 Expression of multiple UCPs in brown adipocytes: function and regulation 109 -- 7.3.4 Induction of emergence of 'ectopic' brown adipocytes in WAT 109 -- 7.3.5 Is there more than one type of brown adipocyte? 110 -- 7.4 Physiological functions of brown adipose tissue 112 -- 7.4.1 Role in thermoregulation in a cold environment 112 -- 7.4.2 Role in food intake 113 -- 7.4.3 Role in defence against obesity 113 -- 7.5 Secretions from brown adipocytes 115 -- 7.5.1 Satiety factors 115 -- 7.5.2 Other factors 116 -- 7.6 [beta subscript 3]ARs in brown and white adipocytes as a target for anti-obesity and anti-diabetes drugs 117 -- 7.7 Perspective 119 -- 8".
catalog tableOfContents "Putative '[beta subscript 4]'-Adrenoreceptor and Other Atypical [beta]-Adrenoreceptors / A. Donny Strosberg, Jonathan R.S. Arch 120 -- 8.2 Pharmacology of the [beta subscript 4]AR and other atypical [beta]ARs 120 -- 8.3 A summary of '[beta subscript 4]'AR pharmacology 121 -- 8.4 Search for molecular evidence for atypical [beta]ARs 123 -- 8.4.1 Discovery of the [beta subscript 3]AR gene and other putative homologues 123 -- 8.4.2 Discovery of a receptor which binds iodocyanopindolol and other3 [beta subscript 3]AR ligands 123 -- 8.4.3 Non-[beta subscript 3]AR-like pharmacological properties of [beta subscript 3]AR proteins 123.".
catalog tableOfContents "[Beta subscript 3]-adrenoreceptor is resistant to rapid agonist-promoted uncoupling and sequestration 29 -- 2.5 Cell type-specific down-regulation of the [beta subscript 3]-adrenoreceptor 30 -- 2.6 Use of chimeric [beta subscript 3]/[beta subscript 2]-adrenoreceptors to delineate regulatory motifs 33 -- 2.7 Potential physiological consequences of the relative resistance of the [beta subscript 3]-adrenoreceptor to desensitization 34 -- 3 Using Transgenic and Gene Knockout Techniques to Assess [beta subscript 3]-Adrenoreceptor Function / Bradford B. Lowell, Vedrana S. Susulic, Danica Grujic, Moriko Ito 36 -- 3.2 Mice lacking [beta subscript 3]AR 36 -- 3.2.1 Phenotype of mice lacking [beta subscript 3]AR 36 -- 3.2.2 Effects of [beta subscript 3]AR deficiency on catecholamine-mediated stimulation of adenylyl cyclase and lipolysis in adipocytes 38 -- 3.2.3 Effects of [beta subscript 3]AR deficiency on in vivo effects of CL-316,243 40 --".
catalog tableOfContents "[beta subscript 3]-Adrenoreceptor Ligands and the Pharmacology of the [beta subscript 3]-Adrenoreceptor / Jonathan R.S. Arch 48 -- 4.2 Antagonists 49 -- 4.2.1 [beta subscript 1/2]AR-selective antagonists 49 --3 4.2.2 Non-selective and [beta subscript 3]AR-selective antagonists 52 -- 4.3 Agonists 55 -- 4.3.1 [beta subscript 1/2]AR-selective agonists 55 -- 4.3.2 Arylethanolamine [beta subscript 3]AR-selective agonists 55 -- 4.3.3 Aryloxypropanolamine [beta subscript 3]AR agonists 66 -- 4.3.4 Trimetoquinol and analogues 72 -- 4.3.5 Metabolism and pharmacokinetics 73 -- 4.4 Idiosyncrasies of [beta subscript 3]AR pharmacology 74 -- 4.4.1 Relative agonist potencies vary with the nature of the assay 74 -- 4.4.2 Prediction of human tissue pharmacology from cloned receptor pharmacology 75 -- 5 Native Human [beta subscript 3]-Adrenoreceptor / Peter Arner, Fredrik Lonnqvist 77 -- 5.2".
catalog title "Beta 3 adrenoreceptor".
catalog title "The B₃-adrenoreceptor / edited by A. Donny Strosberg.".
catalog type "text".