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- catalog abstract "This volume focuses on the relationship between the nervous and the immune system with regard to the effects of drugs of abuse and infections, including infection caused by the immunodeficiency virus which causes AIDS, the number one health problem worldwide. Chapters focus on the brain-immune axis, detailing the effects of drugs of abuse. It is well known that recreational drugs of abuse such as morphine, cocaine, and marijuana, as well as other drugs, including the legal drugs alcohol and nicotine, are used by large numbers of individuals. Serious concerns have been raised about the consequences of using such drugs, especially in relation to their effects on normal physiological responses, including immune mechanisms. It is now widely recognized not only that many drugs of abuse have serious consequences on normal parameters of neurologic and neuroendocrine systems in general but also that effects on those systems, in turn, may affect indirectly immunity and also directly affect immune systems. Much data has now been accumulated showing that drugs of abuse markedly alter the immune response in human populations as well as in experimental animals, both in vivo and in vitro. Furthermore, studies on microbial infections have shown that many drugs of abuse are associated with increased susceptibility to infectious diseases, especially opportunistic intracellular microorganisms, including viruses such as HIV which causes AIDS. The mechanisms whereby drugs of abuse increase the likelihood of infections by opportunistic microorganisms in humans as well as in experimental animals are delineated. This volume will further the understanding of the impact of drugs of abuse on the brain-immune axis and its relationship to immunomodulation and infection, especially that caused by the AIDS virus.".
- catalog contributor b12368452.
- catalog contributor b12368453.
- catalog contributor b12368454.
- catalog contributor b12368455.
- catalog contributor b12368456.
- catalog contributor b12368457.
- catalog created "c2001.".
- catalog date "2001".
- catalog date "c2001.".
- catalog dateCopyrighted "c2001.".
- catalog description "Acute effects of heroin on the cellularity of the spleen and the apoptosis of splenic leukocytes / Karamarie Fecho -- Alteration of early t cell development by opioid and superantigen stimulation / Lois E. McCarthy -- Effects of opioids on oral salmonella infection and immune function / Toby K. Eisenstein -- Altered t-cell responsiveness in morphine "tolerant" rats: evidence for a potential role of the paraventricular nucleus of the hypothalamus / R. Daniel Mellon -- Actions of endotoxin and morphine / Sulie L. Chang -- Pharmaconeuroimmunology of the intestinal tract: opioid and cannabinoid receptors, enteric neurons and mucosal defense / David R. Brown -- Cannabinoid-mediated inhibition of inducible nitric oxide production by rat microglial cells: evidence for CB1 receptor participation / Guy A. Cabral -- Modulation of CB1 mRNA upon activation of murine splenocytes / Sasha N. Noe -- ".
- catalog description "Crosstalk between chemokine and opioid receptors: results in down-modulation of cell migration / Imre Szabo -- Morphine upregulates kappa-opioid receptors of human lymphocytes / Shunji Suzuki -- Effects of morphine on t-cell recirculation in rhesus monkeys / Robert M. Donahoe -- Mitogen-induced activation of mouse t cells increases kappa opioid receptor expression / Jean M. Bidlack -- Self-enhancement of phagocytosis by murine resident peritoneal macrophages and its relationship to morphine effects on the process / Wanda E. Pagán -- Role of mu-opioid receptor in immune function / Sabita Roy -- Opiates promote t cell apoptosis through JNK and caspase pathway / Pravin Singhal -- Role of beta-endorphin in the modulation of immune responses: perspectives in autoimmune diseases / Paola Sacerdote -- Modulation of FAS/FASL in a murine retroviral infection by AZT and methionine enkephalin / Rebecca Bowden -- ".
- catalog description "Downregulation of cannabinoid receptor 2 (CB2) messenger RNA expression during in vitro stimulation of murine splenocytes with lipopolysaccharide / Sume Fong Lee -- CB1 and CB2 receptor mRNA expression in human peripheral blood mononuclear cells (pbMC) from various donor types / Lian Nong -- Effect of cocaine on chemokine and CCR-5 gene expression by mononuclear cells from normal donors and HIV-1 infected patients / Madhavan P.N. Nair -- Intravenous cocaine abuse: a rodent model for potential interactions with HIV proteins / A.K. Bansal -- Substance P receptor mediated macrophage responses / Ian Marriott -- Lymphocyte modulation by seven transmembrane receptors: a brief review of session I / Burt M. Sharp -- NEUROAIDS retroviral pathology and drugs of abuse: session summary / Phillip K. Peterson -- The effects of drugs and neuropeptides on immunomodulation and opportunistic infection: summary of symposium 2 / Toby K. Eisenstein.".
- catalog description "Includes bibliographical references and index.".
- catalog description "Targeting the brain's immune system: a psychopharmacological approach to central nervous system infections / Phillip K. Peterson -- Model systems for assessing cognitive function: implications for HIV-1 infection and drugs of abuse / Walter E. Zink -- Direct and indirect mechanisms of HIV-1 neuropathogenesis in the human central nervous system / Jean Hou -- Chemokine receptors on brain enothelia -- keys to HIV-1 neuroinvasion? / Milan Fiala -- Neurotrofic factor regulation of human immunodeficiency virus type I replication in human blood-derived macrophages through modulation of coreceptor expression / Sharon M. Harrold -- Direct vs. indirect modulation of complex in vitro human retroviral infections by morphine / Susan Bell Nyland -- Genetic factors involved in central nervous system/immune interactions / Ronald L. Wilder -- Interactions of opioid receptors, chemokines and chemokine receptors / Imre Szabo -- ".
- catalog description "This volume focuses on the relationship between the nervous and the immune system with regard to the effects of drugs of abuse and infections, including infection caused by the immunodeficiency virus which causes AIDS, the number one health problem worldwide. Chapters focus on the brain-immune axis, detailing the effects of drugs of abuse. It is well known that recreational drugs of abuse such as morphine, cocaine, and marijuana, as well as other drugs, including the legal drugs alcohol and nicotine, are used by large numbers of individuals. Serious concerns have been raised about the consequences of using such drugs, especially in relation to their effects on normal physiological responses, including immune mechanisms. It is now widely recognized not only that many drugs of abuse have serious consequences on normal parameters of neurologic and neuroendocrine systems in general but also that effects on those systems, in turn, may affect indirectly immunity and also directly affect immune systems. Much data has now been accumulated showing that drugs of abuse markedly alter the immune response in human populations as well as in experimental animals, both in vivo and in vitro. Furthermore, studies on microbial infections have shown that many drugs of abuse are associated with increased susceptibility to infectious diseases, especially opportunistic intracellular microorganisms, including viruses such as HIV which causes AIDS. The mechanisms whereby drugs of abuse increase the likelihood of infections by opportunistic microorganisms in humans as well as in experimental animals are delineated. This volume will further the understanding of the impact of drugs of abuse on the brain-immune axis and its relationship to immunomodulation and infection, especially that caused by the AIDS virus.".
- catalog extent "x, 274 p. :".
- catalog identifier "0306464667".
- catalog isPartOf "Advances in experimental medicine and biology ; v. 493".
- catalog issued "2001".
- catalog issued "c2001.".
- catalog language "eng".
- catalog publisher "New York : Kluwer Academic/Plenum Publishers,".
- catalog subject "616.8/0479 21".
- catalog subject "Communicable Diseases immunology Congresses.".
- catalog subject "Communicable Diseases immunology".
- catalog subject "Drugs of abuse Immunology Congresses.".
- catalog subject "HIV Infections immunology Congresses.".
- catalog subject "HIV Infections immunology".
- catalog subject "HIV infections Congresses.".
- catalog subject "Immune Tolerance drug effects Congresses.".
- catalog subject "Immune Tolerance drug effects".
- catalog subject "Immunosuppression Congresses.".
- catalog subject "Infection Congresses.".
- catalog subject "Neuroimmunology Congresses.".
- catalog subject "Neuroimmunomodulation drug effects Congresses.".
- catalog subject "Neuroimmunomodulation drug effects".
- catalog subject "QV 38 S9911n 2001".
- catalog subject "RM316 .N485 2001".
- catalog subject "Street Drugs immunology Congresses.".
- catalog subject "Street Drugs immunology".
- catalog subject "W1 AD559 v.493 2001".
- catalog tableOfContents "Acute effects of heroin on the cellularity of the spleen and the apoptosis of splenic leukocytes / Karamarie Fecho -- Alteration of early t cell development by opioid and superantigen stimulation / Lois E. McCarthy -- Effects of opioids on oral salmonella infection and immune function / Toby K. Eisenstein -- Altered t-cell responsiveness in morphine "tolerant" rats: evidence for a potential role of the paraventricular nucleus of the hypothalamus / R. Daniel Mellon -- Actions of endotoxin and morphine / Sulie L. Chang -- Pharmaconeuroimmunology of the intestinal tract: opioid and cannabinoid receptors, enteric neurons and mucosal defense / David R. Brown -- Cannabinoid-mediated inhibition of inducible nitric oxide production by rat microglial cells: evidence for CB1 receptor participation / Guy A. Cabral -- Modulation of CB1 mRNA upon activation of murine splenocytes / Sasha N. Noe -- ".
- catalog tableOfContents "Crosstalk between chemokine and opioid receptors: results in down-modulation of cell migration / Imre Szabo -- Morphine upregulates kappa-opioid receptors of human lymphocytes / Shunji Suzuki -- Effects of morphine on t-cell recirculation in rhesus monkeys / Robert M. Donahoe -- Mitogen-induced activation of mouse t cells increases kappa opioid receptor expression / Jean M. Bidlack -- Self-enhancement of phagocytosis by murine resident peritoneal macrophages and its relationship to morphine effects on the process / Wanda E. Pagán -- Role of mu-opioid receptor in immune function / Sabita Roy -- Opiates promote t cell apoptosis through JNK and caspase pathway / Pravin Singhal -- Role of beta-endorphin in the modulation of immune responses: perspectives in autoimmune diseases / Paola Sacerdote -- Modulation of FAS/FASL in a murine retroviral infection by AZT and methionine enkephalin / Rebecca Bowden -- ".
- catalog tableOfContents "Downregulation of cannabinoid receptor 2 (CB2) messenger RNA expression during in vitro stimulation of murine splenocytes with lipopolysaccharide / Sume Fong Lee -- CB1 and CB2 receptor mRNA expression in human peripheral blood mononuclear cells (pbMC) from various donor types / Lian Nong -- Effect of cocaine on chemokine and CCR-5 gene expression by mononuclear cells from normal donors and HIV-1 infected patients / Madhavan P.N. Nair -- Intravenous cocaine abuse: a rodent model for potential interactions with HIV proteins / A.K. Bansal -- Substance P receptor mediated macrophage responses / Ian Marriott -- Lymphocyte modulation by seven transmembrane receptors: a brief review of session I / Burt M. Sharp -- NEUROAIDS retroviral pathology and drugs of abuse: session summary / Phillip K. Peterson -- The effects of drugs and neuropeptides on immunomodulation and opportunistic infection: summary of symposium 2 / Toby K. Eisenstein.".
- catalog tableOfContents "Targeting the brain's immune system: a psychopharmacological approach to central nervous system infections / Phillip K. Peterson -- Model systems for assessing cognitive function: implications for HIV-1 infection and drugs of abuse / Walter E. Zink -- Direct and indirect mechanisms of HIV-1 neuropathogenesis in the human central nervous system / Jean Hou -- Chemokine receptors on brain enothelia -- keys to HIV-1 neuroinvasion? / Milan Fiala -- Neurotrofic factor regulation of human immunodeficiency virus type I replication in human blood-derived macrophages through modulation of coreceptor expression / Sharon M. Harrold -- Direct vs. indirect modulation of complex in vitro human retroviral infections by morphine / Susan Bell Nyland -- Genetic factors involved in central nervous system/immune interactions / Ronald L. Wilder -- Interactions of opioid receptors, chemokines and chemokine receptors / Imre Szabo -- ".
- catalog title "Neuroimmune circuits, drugs of abuse, and infectious diseases / edited by Herman Friedman, Thomas W. Klein, and John J. Madden.".
- catalog type "Congresses".
- catalog type "text".