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catalog alternative "Genes and signals".
catalog contributor b12459132.
catalog contributor b12459133.
catalog created "c2002.".
catalog date "2002".
catalog date "c2002.".
catalog dateCopyrighted "c2002.".
catalog description "122 -- Detecting and Transmitting Physiological Signals 123 -- Transport Into and Out of the Nucleus 123 -- Phosphorylation of Inhibitor or Activator in the Nucleus 124 -- Panel: Transport-dependent Proteolysis: The Case of SREBP 125 -- Allosteric Change of DNA-bound Activator 126 -- Signal Integration, Combinatorial Control, and Alternative Enhancers 126 -- The Human Interferon-[beta] Enhancer 126 -- The Drosophila eve Gene 128 -- Action at a Distance 129 -- Dna Methylation, Insulators, and Imprinting 132 -- Chromosomal Position and Gene Expression 134 -- Compartmentalization 135 -- Chapter 4 Enzyme Specificity and Regulation 143 -- Ubiquitylation and Proteolysis 144 -- Splicing 146 -- Imposing Specificity on Kinases 148 -- Cyclin-dependent Kinases 149 -- Transcriptional Antitermination by TAT 150 -- Cytokine Receptors and Signaling through STATs 152 -- Growth Factor Receptors 154 --".
catalog description "39 -- Activation: A Closer Look 39 -- DNA binding: A Closer Look 41 -- Synergy 41 -- Polymerase Activation: glnA and Related Genes 42 -- Promoter Recognition by [sigma superscript 54]-containing Polymerase 43 -- DNA Binding by NtrC 43 -- Detecting the Physiological Signal 43 -- Activation by NtrC 43 -- Other Activators of [sigma superscript 54] Polymerase 45 -- Interim Summary 45 -- Panel: Phage T4 Late Genes 47 -- Promoter Activation: merT and Related Genes 47 -- Promoter Recognition 47 -- Detecting the Physiological Signal and Activation 48 -- Interim Summary 48 -- Panel: More on Repression in Bacteria 51 -- Chapter 2 Yeast: A Single-celled Eukaryote 59 -- Rna Polymerase 60 -- Other Parts of the Transcriptional Machinery 60 -- An Overview of Activation 63 -- A Model Case: The Gal Genes 63 -- Overview of Regulation of a GAL Gene 64 -- Specific DNA Binding 65 --".
catalog description "Chapter 1 Lessons from Bacteria 11 -- Rna Polymerase 11 -- Regulated Recruitment: The lac Genes 13 -- Protein-DNA Interactions 15 -- Detecting Physiological Signals 16 -- Promoter Recognition and Transcription by RNA Polymerase 17 -- Switching the Genes On: Activation by CAP 18 -- Cooperative Binding of Proteins to DNA 18 -- Cooperative Binding and Gene Activation by CAP 21 -- Repression by Lac Repressor 25 -- Interim Summary and Extension 25 -- More Regulated Recruitment: The Bacteriophage [lambda] 26 -- The Switch 28 -- Establishing Lysogeny 29 -- Analogies with lac 31 -- Promoters 32 -- Protein-DNA Interactions 32 -- Repression 32 -- Activation 32 -- Detecting Physiological Signals 33 -- Making an Efficient Switch 34 -- Cooperative Binding of [lambda] Repressor to DNA 34 -- Autogenous Control by Repressor 37 -- Panel: Antitermination: N and Q 38 -- Interim Summary and Extensions".
catalog description "Detecting Physiological Signals 66 -- How Gal4 Works 67 -- Separate DNA-binding and Activating Regions of Gal4 67 -- Activating Region Structure 71 -- Independent Mutations Can Increase Activator Strength Additively When Combined 72 -- Activating Regions Work with an Efficiency Proportional to Their Lengths 72 -- Activating Region-Target Interactions Tolerate Sequence Changes 73 -- New Activating Regions Are Easily Generated 73 -- Squelching 75 -- Recruitment Visualized 76 -- Activator Bypass Experiments 76 -- Activation by a Heterologous Protein-Protein Interaction 78 -- Direct Tethering of the Transcriptional Machinery 80 -- Panel: Activator Bypass Experiments 81 -- How does Gal4 Recruit Polymerase? 82 -- Nucleosomes and Their Modifiers 83 -- Targets of Gal4: Experiments Performed In Vitro 84 -- Action of Gal4: Experiments Performed In Vivo 85 -- What Is Required for Activation? 86 --".
catalog description "Includes bibliographical references and index.".
catalog description "Interim Summary and Extensions 156 -- Kinases 157 -- Phosphatases 158 -- Interpreting Signals 159 -- Further Generalizations 160 -- Dangers 160 -- Interpreting Experiments 162 -- Benefits 163 -- Appendix 1 More on Cooperativity 177 -- Appendix 2 Topogenic Sequences 183 -- Appendix 3 All-or-none Effects and Levels of Gene Expression 185.".
catalog description "What Appears at the Gene Upon Activation? 86 -- Imposing a Need for Nucleosome Modifiers 87 -- Weakening the Gal4-binding Sites or the Gal4-activating region 87 -- Cell-cycle Stage-dependent Requirement for Nucleosome Modifiers 89 -- Activation: An Interim Summary 89 -- Repression by Mig1 91 -- Signal Integration and Combinatorial Control 92 -- Cooperative Binding with Alternative Partners 93 -- Sequential Binding of Activators 94 -- Silencing 95 -- Heterochromatic Chromosomal Regions 95 -- Compartmentalization 98 -- Panel: Variegation Visualized 99 -- Panel: Epigenetics 100 -- DNA Looping 101 -- Chapter 3 Some Notes on Higher Eukaryotes 115 -- Mechanism of Activation: Recruitment 116 -- What is Recruited? 118 -- Transcriptional Machinery and Promoters 118 -- Nucleosomal Templates 119 -- Targets 119 -- The Human Interferon-[beta] Gene 121 -- The Drosophila HSP70 Gene 122 -- Repression".
catalog extent "xvi, 192 p. :".
catalog identifier "0879696311 (cloth)".
catalog identifier "0879696338 (pbk.)".
catalog issued "2002".
catalog issued "c2002.".
catalog language "eng".
catalog publisher "Cold Spring Harbor, N.Y. : Cold Spring Harbor Laboratory Press,".
catalog subject "572.8/65 21".
catalog subject "Gene Expression Regulation.".
catalog subject "Genetic regulation.".
catalog subject "QH 450 P975g 2002".
catalog subject "QH450 .P83 2002".
catalog tableOfContents "122 -- Detecting and Transmitting Physiological Signals 123 -- Transport Into and Out of the Nucleus 123 -- Phosphorylation of Inhibitor or Activator in the Nucleus 124 -- Panel: Transport-dependent Proteolysis: The Case of SREBP 125 -- Allosteric Change of DNA-bound Activator 126 -- Signal Integration, Combinatorial Control, and Alternative Enhancers 126 -- The Human Interferon-[beta] Enhancer 126 -- The Drosophila eve Gene 128 -- Action at a Distance 129 -- Dna Methylation, Insulators, and Imprinting 132 -- Chromosomal Position and Gene Expression 134 -- Compartmentalization 135 -- Chapter 4 Enzyme Specificity and Regulation 143 -- Ubiquitylation and Proteolysis 144 -- Splicing 146 -- Imposing Specificity on Kinases 148 -- Cyclin-dependent Kinases 149 -- Transcriptional Antitermination by TAT 150 -- Cytokine Receptors and Signaling through STATs 152 -- Growth Factor Receptors 154 --".
catalog tableOfContents "39 -- Activation: A Closer Look 39 -- DNA binding: A Closer Look 41 -- Synergy 41 -- Polymerase Activation: glnA and Related Genes 42 -- Promoter Recognition by [sigma superscript 54]-containing Polymerase 43 -- DNA Binding by NtrC 43 -- Detecting the Physiological Signal 43 -- Activation by NtrC 43 -- Other Activators of [sigma superscript 54] Polymerase 45 -- Interim Summary 45 -- Panel: Phage T4 Late Genes 47 -- Promoter Activation: merT and Related Genes 47 -- Promoter Recognition 47 -- Detecting the Physiological Signal and Activation 48 -- Interim Summary 48 -- Panel: More on Repression in Bacteria 51 -- Chapter 2 Yeast: A Single-celled Eukaryote 59 -- Rna Polymerase 60 -- Other Parts of the Transcriptional Machinery 60 -- An Overview of Activation 63 -- A Model Case: The Gal Genes 63 -- Overview of Regulation of a GAL Gene 64 -- Specific DNA Binding 65 --".
catalog tableOfContents "Chapter 1 Lessons from Bacteria 11 -- Rna Polymerase 11 -- Regulated Recruitment: The lac Genes 13 -- Protein-DNA Interactions 15 -- Detecting Physiological Signals 16 -- Promoter Recognition and Transcription by RNA Polymerase 17 -- Switching the Genes On: Activation by CAP 18 -- Cooperative Binding of Proteins to DNA 18 -- Cooperative Binding and Gene Activation by CAP 21 -- Repression by Lac Repressor 25 -- Interim Summary and Extension 25 -- More Regulated Recruitment: The Bacteriophage [lambda] 26 -- The Switch 28 -- Establishing Lysogeny 29 -- Analogies with lac 31 -- Promoters 32 -- Protein-DNA Interactions 32 -- Repression 32 -- Activation 32 -- Detecting Physiological Signals 33 -- Making an Efficient Switch 34 -- Cooperative Binding of [lambda] Repressor to DNA 34 -- Autogenous Control by Repressor 37 -- Panel: Antitermination: N and Q 38 -- Interim Summary and Extensions".
catalog tableOfContents "Detecting Physiological Signals 66 -- How Gal4 Works 67 -- Separate DNA-binding and Activating Regions of Gal4 67 -- Activating Region Structure 71 -- Independent Mutations Can Increase Activator Strength Additively When Combined 72 -- Activating Regions Work with an Efficiency Proportional to Their Lengths 72 -- Activating Region-Target Interactions Tolerate Sequence Changes 73 -- New Activating Regions Are Easily Generated 73 -- Squelching 75 -- Recruitment Visualized 76 -- Activator Bypass Experiments 76 -- Activation by a Heterologous Protein-Protein Interaction 78 -- Direct Tethering of the Transcriptional Machinery 80 -- Panel: Activator Bypass Experiments 81 -- How does Gal4 Recruit Polymerase? 82 -- Nucleosomes and Their Modifiers 83 -- Targets of Gal4: Experiments Performed In Vitro 84 -- Action of Gal4: Experiments Performed In Vivo 85 -- What Is Required for Activation? 86 --".
catalog tableOfContents "Interim Summary and Extensions 156 -- Kinases 157 -- Phosphatases 158 -- Interpreting Signals 159 -- Further Generalizations 160 -- Dangers 160 -- Interpreting Experiments 162 -- Benefits 163 -- Appendix 1 More on Cooperativity 177 -- Appendix 2 Topogenic Sequences 183 -- Appendix 3 All-or-none Effects and Levels of Gene Expression 185.".
catalog tableOfContents "What Appears at the Gene Upon Activation? 86 -- Imposing a Need for Nucleosome Modifiers 87 -- Weakening the Gal4-binding Sites or the Gal4-activating region 87 -- Cell-cycle Stage-dependent Requirement for Nucleosome Modifiers 89 -- Activation: An Interim Summary 89 -- Repression by Mig1 91 -- Signal Integration and Combinatorial Control 92 -- Cooperative Binding with Alternative Partners 93 -- Sequential Binding of Activators 94 -- Silencing 95 -- Heterochromatic Chromosomal Regions 95 -- Compartmentalization 98 -- Panel: Variegation Visualized 99 -- Panel: Epigenetics 100 -- DNA Looping 101 -- Chapter 3 Some Notes on Higher Eukaryotes 115 -- Mechanism of Activation: Recruitment 116 -- What is Recruited? 118 -- Transcriptional Machinery and Promoters 118 -- Nucleosomal Templates 119 -- Targets 119 -- The Human Interferon-[beta] Gene 121 -- The Drosophila HSP70 Gene 122 -- Repression".
catalog title "Genes & signals / Mark Ptashne, Alexander Gann.".
catalog title "Genes and signals".
catalog type "text".