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• catalog abstract ""The idea of the gene has been a central organizing theme in contemporary biology; and the Human Genome Project and biotechnological advances have put the gene in the media spotlight. In this book Lenny Moss reconstructs the history of the gene concept, placing it in the context of the perennial interplay between theories of preformationism and theories of epigenesis. He finds that there are not one, but two, fundamental - and fundamentally different - senses of "the gene" in scientific use: one the heir to preformationism and the other the heir to epigenesis. "Gene-P," the preformationist gene concept, serves as an instrumental predictor of phenotypic outcomes, whereas "Gene-D," the gene of epigenesis, is a developmental resource that specifies possible amino acid sequences for proteins. Moss argues that the popular idea that genes constitute blueprints for organisms is the result of an unwarranted conflation of these independently valid senses of the gene, and he analyzes the rhetorical basis of this conflation." "In the heart of the book, Moss uses the Gene-D/Gene-P distinction to examine the real basis of biological order and of the pathological loss of order in cancer. He provides a detailed analysis of the "order-from-order" role of cell membranes and compartmentalization and considers dynamic approaches to biological order such as that of Stuart Kauffman. He reviews the history of cancer research with an emphasis on the oncogene and tumor suppressor gene models and shows how these gene-centered strategies point back to the significance of higher level, multicellular organization fields in the onset and progression of cancer. Finally, Moss draws on the findings of the Human Genome Project, biological modularity, and the growing interest in resynthesizing theories of evolution and development to look beyond the "century of the gene" toward a rebirth of biological understanding."--Jacket.".
• catalog contributor b12608246.
• catalog created "c2003.".
• catalog date "2003".
• catalog date "c2003.".
• catalog dateCopyrighted "c2003.".
• catalog description ""The idea of the gene has been a central organizing theme in contemporary biology; and the Human Genome Project and biotechnological advances have put the gene in the media spotlight. In this book Lenny Moss reconstructs the history of the gene concept, placing it in the context of the perennial interplay between theories of preformationism and theories of epigenesis. He finds that there are not one, but two, fundamental - and fundamentally different - senses of "the gene" in scientific use: one the heir to preformationism and the other the heir to epigenesis. "Gene-P," the preformationist gene concept, serves as an instrumental predictor of phenotypic outcomes, whereas "Gene-D," the gene of epigenesis, is a developmental resource that specifies possible amino acid sequences for proteins. Moss argues that the popular idea that genes constitute blueprints for organisms is the result of an unwarranted conflation of these independently valid senses of the gene, and he analyzes the rhetorical basis of this conflation." "In the heart of the book, Moss uses the Gene-D/Gene-P distinction to examine the real basis of biological order and of the pathological loss of order in cancer. He provides a detailed analysis of the "order-from-order" role of cell membranes and compartmentalization and considers dynamic approaches to biological order such as that of Stuart Kauffman. He reviews the history of cancer research with an emphasis on the oncogene and tumor suppressor gene models and shows how these gene-centered strategies point back to the significance of higher level, multicellular organization fields in the onset and progression of cancer. Finally, Moss draws on the findings of the Human Genome Project, biological modularity, and the growing interest in resynthesizing theories of evolution and development to look beyond the "century of the gene" toward a rebirth of biological understanding."--Jacket.".
• catalog description "1. Genesis of the Gene -- 2. The Rhetoric of Life and the Life of Rhetoric -- 3. A Critique of Pure (Genetic) Information -- 4. Dialectics of Disorder: Normalization and Pathology as Process -- 5. After the Gene.".
• catalog description "Includes bibliographical references (p. [205]-215) and index.".
• catalog extent "xx, 228 p. :".
• catalog hasFormat "What genes can't do.".
• catalog identifier "026213411X".
• catalog identifier "9780585441610 (electronic bk.)".
• catalog isFormatOf "What genes can't do.".
• catalog isPartOf "Basic bioethics".
• catalog issued "2003".
• catalog issued "c2003.".
• catalog language "eng".
• catalog publisher "Cambridge, Mass. : MIT Press,".
• catalog relation "What genes can't do.".
• catalog subject "660.6/5 21".
• catalog subject "Genetics Philosophy.".
• catalog subject "Genetics.".
• catalog subject "Philosophy.".
• catalog subject "QH 430 M913w 2003".
• catalog subject "QH430 .M674 2003".
• catalog tableOfContents "1. Genesis of the Gene -- 2. The Rhetoric of Life and the Life of Rhetoric -- 3. A Critique of Pure (Genetic) Information -- 4. Dialectics of Disorder: Normalization and Pathology as Process -- 5. After the Gene.".
• catalog title "What genes can't do / Lenny Moss.".
• catalog type "text".