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• catalog abstract "In recent years, major developments have been made in understanding various genetic and epigenetic regulatory processes that are critical for the generation of B cell repertoires. These include the role of chromatin regulation and nuclear organization in understating the IgH gene regulation. A role and mechanism of DNA repair proteins in somatic hypermutation has been elucidated. Genetic mutation studies have been instrumental in providing insight into some of the mechanisms involved in targeting CSR to various switch DNA regions located upstream of C region genes, especially a role of AID motifs, transcription, and R-loops. Recent studies support a dominant role of receptor editing in central B cell tolerance and signaling pathways that regulate receptor editing in self-reactive and non-self-reactive immature B cells. These were some of the topics of discussion at the 11th International Conference on B cell Biology. These proceedings highlight recent developments in lymphocyte development, Ig gene rearrangements and somatic hypermutation, chromatin structure modification, B lymphocyte signaling and fate, receptor editing, and autoimmunity.".
• catalog contributor b12608249.
• catalog contributor b12608250.
• catalog contributor b12608251.
• catalog contributor b12608252.
• catalog created "c2002.".
• catalog date "2002".
• catalog date "c2002.".
• catalog dateCopyrighted "c2002.".
• catalog description "In recent years, major developments have been made in understanding various genetic and epigenetic regulatory processes that are critical for the generation of B cell repertoires. These include the role of chromatin regulation and nuclear organization in understating the IgH gene regulation. A role and mechanism of DNA repair proteins in somatic hypermutation has been elucidated. Genetic mutation studies have been instrumental in providing insight into some of the mechanisms involved in targeting CSR to various switch DNA regions located upstream of C region genes, especially a role of AID motifs, transcription, and R-loops. Recent studies support a dominant role of receptor editing in central B cell tolerance and signaling pathways that regulate receptor editing in self-reactive and non-self-reactive immature B cells. These were some of the topics of discussion at the 11th International Conference on B cell Biology. These proceedings highlight recent developments in lymphocyte development, Ig gene rearrangements and somatic hypermutation, chromatin structure modification, B lymphocyte signaling and fate, receptor editing, and autoimmunity.".
• catalog description "Includes bibliographical references and index.".
• catalog description "Lymphocyte development in neonatal and adult c-kit-deficient (C-kit w/w) mice -- Development of antigen-specific helper T cell responses in vivo : antigen-specific TH cell subsets -- BCL-6 uncouples B lymphocyte proliferations form differentiation -- The role of vav proteins in B cell responses -- Traffic patterns of B cells and plasma cells -- Lymphocyte traffice in lymphoid organ neogenesis differential roles of L[alpha]T and L[alpha][beta]T -- Regulation of spleen white pulp structure and function by lymphotoxin -- Enzymatic control of leukocyte traficking : role of vap-1 -- Homestatic chemokines and the targeting of regional immunity -- Factors regulating naïve T cells homeostasis -- IL-7, the thymus, and naïve T cells - Neonates support "homeostatic" proliferation -- Self-recognition and the regulation of CD4+ T cell survival -- TCR-independent proliferation and differentiation of human CD⁺4 cell subsets induced by cytokines -- Regulation of memory CD4 T cells : generation, localization and persistence -- Some properties of T cells in animals - Generation and characterization of memory CD4 T cells -- T cell proliferation, differentiation, and restoration in lymphopenic individuals : for contributed volumes -- Migration of primary and memory CD8 T cells -- Cytokines and memory-phenotype CD8 cells -- Antiviral memory T cell responses : correlation with protective immunity and implication for vaccine development -- Homeostatic proliferation but not the generation of virus specific memory CD8 T cells is impaired in the absence of IL-15 or IL-15R -- Irreversible marking of dendritic cells in vivo : for contributed volumes -- Tracking arterial smooth muscle specific T cells in the inflamed vasculature -- Regulation of T cell migration through formation of immunological synapses : the stop signal hypothesis -- Two-photon imaging in intact lymphoid tissue.".
• catalog extent "ix, 212 p., [1] p. of plate :".
• catalog identifier "030647395X".
• catalog isPartOf "Advances in experimental medicine and biology ; v. 512".
• catalog issued "2002".
• catalog issued "c2002.".
• catalog language "eng".
• catalog publisher "New York : Kluwer Academic/Plenum Publishers,".
• catalog subject "616.07/9 21".
• catalog subject "Cell Movement Congresses.".
• catalog subject "Cell Movement".
• catalog subject "Cells Motility Congresses.".
• catalog subject "Immune response Regulation Congresses.".
• catalog subject "Immune response Regulations Congresses.".
• catalog subject "Lymphocyte Activation Congresses.".
• catalog subject "Lymphocyte Activation".
• catalog subject "Lymphocyte transformation Congresses.".
• catalog subject "Lymphocytes immunology".
• catalog subject "Lymphocytes physiology Congresses.".
• catalog subject "Lymphocytes physiology".
• catalog subject "QR185.8.L9 I553 2002".
• catalog subject "W1 AD559 v.512 2002".
• catalog subject "WH 200 I572L 2002".
• catalog tableOfContents "Lymphocyte development in neonatal and adult c-kit-deficient (C-kit w/w) mice -- Development of antigen-specific helper T cell responses in vivo : antigen-specific TH cell subsets -- BCL-6 uncouples B lymphocyte proliferations form differentiation -- The role of vav proteins in B cell responses -- Traffic patterns of B cells and plasma cells -- Lymphocyte traffice in lymphoid organ neogenesis differential roles of L[alpha]T and L[alpha][beta]T -- Regulation of spleen white pulp structure and function by lymphotoxin -- Enzymatic control of leukocyte traficking : role of vap-1 -- Homestatic chemokines and the targeting of regional immunity -- Factors regulating naïve T cells homeostasis -- IL-7, the thymus, and naïve T cells - Neonates support "homeostatic" proliferation -- Self-recognition and the regulation of CD4+ T cell survival -- TCR-independent proliferation and differentiation of human CD⁺4 cell subsets induced by cytokines -- Regulation of memory CD4 T cells : generation, localization and persistence -- Some properties of T cells in animals - Generation and characterization of memory CD4 T cells -- T cell proliferation, differentiation, and restoration in lymphopenic individuals : for contributed volumes -- Migration of primary and memory CD8 T cells -- Cytokines and memory-phenotype CD8 cells -- Antiviral memory T cell responses : correlation with protective immunity and implication for vaccine development -- Homeostatic proliferation but not the generation of virus specific memory CD8 T cells is impaired in the absence of IL-15 or IL-15R -- Irreversible marking of dendritic cells in vivo : for contributed volumes -- Tracking arterial smooth muscle specific T cells in the inflamed vasculature -- Regulation of T cell migration through formation of immunological synapses : the stop signal hypothesis -- Two-photon imaging in intact lymphoid tissue.".
• catalog title "Lymphocyte activation and immune regulation IX : homeostasis and lymphocyte traffic / edited by Sudhir Gupta, Eugene Butcher, and William Paul.".
• catalog type "Conference proceedings. fast".
• catalog type "Congresses".
• catalog type "text".