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- catalog abstract "This book deals with the regulation of ions in brain extra- and intracellular fluids. After an introduction to the electrophysiology of epilepsy, and a description of experimental seizure "models," the second part discusses the roles of the faulty regulation of ions and of the diseases of ion channels in generating epileptic seizures. The mechanisms of action of various anticonvulsant drugs are also considered. The third part is devoted to the phenomenon of spreading depression and its likely role in human diseases. The final chapters of the book deal with the role of ions in the devastation caused by lack of oxygen and by insufficient blood flow to brain tissue, and the reasons for the exceptional vulnerability of certain classes of central neurons in hypoxia and stroke. The book will be of interest to neuroscientists, neurobiologists, neurophysiologists, neurologists, neurosurgeons, and to their students and trainees.".
- catalog contributor b13196350.
- catalog created "2004.".
- catalog date "2004".
- catalog date "2004.".
- catalog dateCopyrighted "2004.".
- catalog description "Includes bibliographical references and index.".
- catalog description "The blood-brain barrier -- The regulation of brain ions -- Osmotic stress and the brain -- The influence of ion concentrations on neuron functions -- A primer of epileptiform seizures -- Experimental seizures -- Electrophysiology of seizures -- Ions and seizures -- Solving seizure mechanisms by simulations -- Seizures, channels, genes -- Mechanisms of action of antiepileptic drugs -- Introduction to speading depression: extracellular electric signs -- Ion fluxes during spreading depression -- Membrane potential and input resistance during spreading depression -- The mechanism of spreading depression -- Solving the puzzle of spreading depression by computer simulation -- Hypoxia, asphyxia, and ischemia -- Mechanism of early, reversible hypoxic synaptic failure -- Irreversible hypoxic (ischemic) neuron injury.".
- catalog description "This book deals with the regulation of ions in brain extra- and intracellular fluids. After an introduction to the electrophysiology of epilepsy, and a description of experimental seizure "models," the second part discusses the roles of the faulty regulation of ions and of the diseases of ion channels in generating epileptic seizures. The mechanisms of action of various anticonvulsant drugs are also considered. The third part is devoted to the phenomenon of spreading depression and its likely role in human diseases. The final chapters of the book deal with the role of ions in the devastation caused by lack of oxygen and by insufficient blood flow to brain tissue, and the reasons for the exceptional vulnerability of certain classes of central neurons in hypoxia and stroke. The book will be of interest to neuroscientists, neurobiologists, neurophysiologists, neurologists, neurosurgeons, and to their students and trainees.".
- catalog extent "xxix, 470 p. :".
- catalog hasFormat "Ions in the brain.".
- catalog identifier "0195151712 (cloth : alk. paper)".
- catalog isFormatOf "Ions in the brain.".
- catalog issued "2004".
- catalog issued "2004.".
- catalog language "eng".
- catalog publisher "Oxford ; New York : Oxford University Press,".
- catalog relation "Ions in the brain.".
- catalog subject "616.8/047 21".
- catalog subject "Brain Diseases physiopathology.".
- catalog subject "Brain Pathophysiology.".
- catalog subject "Brain physiopathology.".
- catalog subject "Cerebrovascular disease Pathophysiology.".
- catalog subject "Epilepsy Pathophysiology.".
- catalog subject "Ion channels.".
- catalog subject "Ions metabolism.".
- catalog subject "Neural transmission.".
- catalog subject "Neurochemistry.".
- catalog subject "Neurotransmission.".
- catalog subject "RC386.2 .S66 2004".
- catalog subject "WL 348 S696i 2004".
- catalog tableOfContents "The blood-brain barrier -- The regulation of brain ions -- Osmotic stress and the brain -- The influence of ion concentrations on neuron functions -- A primer of epileptiform seizures -- Experimental seizures -- Electrophysiology of seizures -- Ions and seizures -- Solving seizure mechanisms by simulations -- Seizures, channels, genes -- Mechanisms of action of antiepileptic drugs -- Introduction to speading depression: extracellular electric signs -- Ion fluxes during spreading depression -- Membrane potential and input resistance during spreading depression -- The mechanism of spreading depression -- Solving the puzzle of spreading depression by computer simulation -- Hypoxia, asphyxia, and ischemia -- Mechanism of early, reversible hypoxic synaptic failure -- Irreversible hypoxic (ischemic) neuron injury.".
- catalog title "Ions in the brain : normal function, seizures, and stroke / George G. Somjen.".
- catalog type "text".