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- catalog abstract "This volume is concerned with the hallmark "relapse" or "drug resistance" phenomena that face the practicing oncologist on a daily basis and it serves as a translational reference for clinical applications. It covers the increasing evidence that impaired expression/activity of at least some of the DNA repair proteins account for tumor cell resistance to particular therapeutic agents. This book summarizes timely in-depth reviews covering the latest developments that have potential for translational and clinical applications and represents the first volume dedicated to the translational aspect of DNA repair in the clinic.".
- catalog contributor b13196365.
- catalog contributor b13196366.
- catalog created "c2004.".
- catalog date "2004".
- catalog date "c2004.".
- catalog dateCopyrighted "c2004.".
- catalog description "Cellular protection against the antitumor drug bleomycin -- Potential role of PARP inhibitors in cancer treatment and cell death -- Relationship among DNA repair genes, cellular radiosensitivity, and the response of tumors and normal tissues to radiotherapy -- Strand-break repair and radiation resistance -- V(D)J recombination and DNA double-strand-break repair: from immune deficiency to tumorigenesis -- Inherited disorders of genomic instability and cancer susceptibility -- Role of BRCA1 and BRCA2 in DNA repair and potential impact on therapeutics -- Genetic variations in DNA repair: their implications in human cancer risk, prevention, and therapy.".
- catalog description "Clinical resistance to alkylators: status and perspective -- Role of nonhomologous end-joining and recombinational DNA repair in resistance to nitrogen mustard and DNA crosslinking agents -- Repair of DNA interstrnad crosslinks produced by cancer chemotherapeutic drugs -- Chemosensitization to platinum-based anticancer drugs: current trends and future prospects -- Regulation of DNA repair and apoptosis by p53 and its impact on alkylating drug resistance of tumor cells -- Stress-activated signal transduction pathways in DNA damage response: implications for repair, arrest, and therapeutic interventions -- Overcoming resistance to alkylating agents by inhibitors of O⁶-alkylguanine-DNA alkyltransferase.".
- catalog description "Includes bibliographical references and index.".
- catalog description "This volume is concerned with the hallmark "relapse" or "drug resistance" phenomena that face the practicing oncologist on a daily basis and it serves as a translational reference for clinical applications. It covers the increasing evidence that impaired expression/activity of at least some of the DNA repair proteins account for tumor cell resistance to particular therapeutic agents. This book summarizes timely in-depth reviews covering the latest developments that have potential for translational and clinical applications and represents the first volume dedicated to the translational aspect of DNA repair in the clinic.".
- catalog extent "xi, 362 p. :".
- catalog hasFormat "DNA repair in cancer therapy.".
- catalog identifier "1588292983 (alk. paper)".
- catalog isFormatOf "DNA repair in cancer therapy.".
- catalog isPartOf "Cancer drug discovery and development".
- catalog issued "2004".
- catalog issued "c2004.".
- catalog language "eng".
- catalog publisher "Totowa, N.J. : Humana Press,".
- catalog relation "DNA repair in cancer therapy.".
- catalog subject "616.99/4061 22".
- catalog subject "Antimutagens Therapeutic use.".
- catalog subject "Cancer Chemotherapy.".
- catalog subject "DNA Repair.".
- catalog subject "DNA repair.".
- catalog subject "Neoplasms drug therapy.".
- catalog subject "Neoplasms genetics.".
- catalog subject "QZ 267 D6296 2004".
- catalog subject "RC271.A684 D63 2004".
- catalog tableOfContents "Cellular protection against the antitumor drug bleomycin -- Potential role of PARP inhibitors in cancer treatment and cell death -- Relationship among DNA repair genes, cellular radiosensitivity, and the response of tumors and normal tissues to radiotherapy -- Strand-break repair and radiation resistance -- V(D)J recombination and DNA double-strand-break repair: from immune deficiency to tumorigenesis -- Inherited disorders of genomic instability and cancer susceptibility -- Role of BRCA1 and BRCA2 in DNA repair and potential impact on therapeutics -- Genetic variations in DNA repair: their implications in human cancer risk, prevention, and therapy.".
- catalog tableOfContents "Clinical resistance to alkylators: status and perspective -- Role of nonhomologous end-joining and recombinational DNA repair in resistance to nitrogen mustard and DNA crosslinking agents -- Repair of DNA interstrnad crosslinks produced by cancer chemotherapeutic drugs -- Chemosensitization to platinum-based anticancer drugs: current trends and future prospects -- Regulation of DNA repair and apoptosis by p53 and its impact on alkylating drug resistance of tumor cells -- Stress-activated signal transduction pathways in DNA damage response: implications for repair, arrest, and therapeutic interventions -- Overcoming resistance to alkylating agents by inhibitors of O⁶-alkylguanine-DNA alkyltransferase.".
- catalog title "DNA repair in cancer therapy / edited by Lawrence C. Panasci and Moulay A. Alaoui-Jamali.".
- catalog type "text".