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- 2005415380 abstract "The second-generation anticoagulant brodifacoum is currently used for possum and rodent control on the New Zealand mainland, and for rodent eradication on offshore islands. To investigate whether these uses have produced undesirable effects in localised wild rat populations (anticoagulant resistance) or in birds (effects on blood coagulation times), blood clotting response tests utilising small-volume sampling were established using albino laboratory rats (Rattus norvegicus, Wistar) and domestic chickens (Gallus domesticus). These tests were then used on blood samples taken from wild rats (R. norvegicus) and kiwi (Apteryx australis mantelli). During the development of the blood-clotting test in laboratory rats we observed a reduced anticoagulant response after a second dose of 0.1 mg/kg of brodifacoum, compared with the initial exposure. There was no evidence of anticoagulant resistance in rats from areas where there was a history of 2.5 years' use of brodifacoum. Statistical differences were found in the clotting times of kiwi from areas with a history of anticoagulant use and those from areas where brodifacoum has not been used, but the clotting times were the opposite of what would be expected if they were interpreted on the basis of exposure history alone. These results highlight uncertainties regarding resistance, sub-lethal effects, threshold concentrations in the liver, and the toxicodynamics of anticoagulants in mammals and birds.".
- 2005415380 alternative "Small-volume blood samples to assess effects of anticoagulant poisons".
- 2005415380 contributor B10281739.
- 2005415380 contributor B10281740.
- 2005415380 contributor B10281741.
- 2005415380 created "c2005.".
- 2005415380 date "2005".
- 2005415380 date "c2005.".
- 2005415380 dateCopyrighted "c2005.".
- 2005415380 description "The second-generation anticoagulant brodifacoum is currently used for possum and rodent control on the New Zealand mainland, and for rodent eradication on offshore islands. To investigate whether these uses have produced undesirable effects in localised wild rat populations (anticoagulant resistance) or in birds (effects on blood coagulation times), blood clotting response tests utilising small-volume sampling were established using albino laboratory rats (Rattus norvegicus, Wistar) and domestic chickens (Gallus domesticus). These tests were then used on blood samples taken from wild rats (R. norvegicus) and kiwi (Apteryx australis mantelli). During the development of the blood-clotting test in laboratory rats we observed a reduced anticoagulant response after a second dose of 0.1 mg/kg of brodifacoum, compared with the initial exposure. There was no evidence of anticoagulant resistance in rats from areas where there was a history of 2.5 years' use of brodifacoum. Statistical differences were found in the clotting times of kiwi from areas with a history of anticoagulant use and those from areas where brodifacoum has not been used, but the clotting times were the opposite of what would be expected if they were interpreted on the basis of exposure history alone. These results highlight uncertainties regarding resistance, sub-lethal effects, threshold concentrations in the liver, and the toxicodynamics of anticoagulants in mammals and birds.".
- 2005415380 extent "22 p. :".
- 2005415380 hasFormat "Also issued electronically via World Wide Web in PDF format.".
- 2005415380 identifier "0478226667".
- 2005415380 identifier SfC249.pdf.
- 2005415380 isFormatOf "Also issued electronically via World Wide Web in PDF format.".
- 2005415380 isPartOf "Science for conservation, 1173-2946 ; 249".
- 2005415380 issued "2005".
- 2005415380 issued "c2005.".
- 2005415380 language "eng".
- 2005415380 publisher "Wellington, N.Z. : Dept. of Conservation,".
- 2005415380 relation "Also issued electronically via World Wide Web in PDF format.".
- 2005415380 spatial "New Zealand.".
- 2005415380 subject "Blood coagulation tests New Zealand.".
- 2005415380 subject "Brodifacoum Toxicology New Zealand.".
- 2005415380 subject "North Island brown kiwi Effect of pesticides on New Zealand.".
- 2005415380 subject "Rattus norvegicus Effect of pesticides on New Zealand.".
- 2005415380 subject "Rodenticide resistance New Zealand.".
- 2005415380 subject "SB951.8 .B35 2005".
- 2005415380 title "Assessing anticoagulant resistance in rats and coagulation effects in birds using small-volume blood samples / C. Bailey, P. Fisher, and C.T. Eason.".
- 2005415380 title "Small-volume blood samples to assess effects of anticoagulant poisons".
- 2005415380 type "text".