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- 2010369282 abstract "This volume is part of the ongoing review of the underlying scientific bases for decision-making in chemical risk assessment by International Program on Chemical Safety. It involves specific consideration of the area of dose-response assessment in the evaluation of information from toxicological studies in animals and from human clinical and epidemiological studies. It covers toxicants with threshold effects and those for which there may be no practical threshold, such as substances that are genotoxic and carcinogenic. The discussions are concerned with that subset of cause-effect relationships commonly referred to as dose-response models, which are typically used to characterize the biological effects of intentional (e.g. drugs and nutrients) and unintentional (e.g. contaminants) exposure to chemicals. This report is intended primarily to provide descriptive guidance for risk assessors in using dose-response modeling in hazard characterization. It will also provide mathematical modelers with an appreciation of issues to be considered when modeling in the context of the risk assessment process. Risk managers will be able to obtain a general understanding of the applications and limitations of dose-response modeling. For both risk assessors and risk managers, some considerations for communicating the results of risk assessments that use dose-response modeling are presented.--Publisher's description.".
- 2010369282 contributor B11886270.
- 2010369282 created "c2009.".
- 2010369282 date "2009".
- 2010369282 date "c2009.".
- 2010369282 dateCopyrighted "c2009.".
- 2010369282 description "Includes bibliographical references (p. 103-110).".
- 2010369282 description "Summary, conclusions, and recommendations -- Introduction -- Risk analysis -- Dose-response modelling : basic concepts -- Dose-response modelling : why and when to use it -- Principles of dose-response modelling -- Communicating the results of dose-response modelling -- Conclusions and recommendations.".
- 2010369282 description "This volume is part of the ongoing review of the underlying scientific bases for decision-making in chemical risk assessment by International Program on Chemical Safety. It involves specific consideration of the area of dose-response assessment in the evaluation of information from toxicological studies in animals and from human clinical and epidemiological studies. It covers toxicants with threshold effects and those for which there may be no practical threshold, such as substances that are genotoxic and carcinogenic. The discussions are concerned with that subset of cause-effect relationships commonly referred to as dose-response models, which are typically used to characterize the biological effects of intentional (e.g. drugs and nutrients) and unintentional (e.g. contaminants) exposure to chemicals. This report is intended primarily to provide descriptive guidance for risk assessors in using dose-response modeling in hazard characterization. It will also provide mathematical modelers with an appreciation of issues to be considered when modeling in the context of the risk assessment process. Risk managers will be able to obtain a general understanding of the applications and limitations of dose-response modeling. For both risk assessors and risk managers, some considerations for communicating the results of risk assessments that use dose-response modeling are presented.--Publisher's description.".
- 2010369282 extent "xx, 137 p. :".
- 2010369282 hasFormat "Also available online.".
- 2010369282 identifier "9241572396".
- 2010369282 identifier "9789241572392".
- 2010369282 identifier 9789241572392_eng.pdf.
- 2010369282 isFormatOf "Also available online.".
- 2010369282 isPartOf "Environmental health criteria ; 239.".
- 2010369282 isPartOf "Environmental health criteria, 0250-863X ; 239".
- 2010369282 issued "2009".
- 2010369282 issued "c2009.".
- 2010369282 language "eng".
- 2010369282 publisher "Geneva, Switzerland : World Health Organization,".
- 2010369282 relation "Also available online.".
- 2010369282 subject "Dose-Response Relationship, Drug.".
- 2010369282 subject "Dose-Response Relationship, Radiation.".
- 2010369282 subject "Drugs Dose-response relationship.".
- 2010369282 subject "Environmental exposure.".
- 2010369282 subject "RM301.8 .P75 2009".
- 2010369282 subject "Risk Assessment.".
- 2010369282 subject "Risk assessment.".
- 2010369282 tableOfContents "Summary, conclusions, and recommendations -- Introduction -- Risk analysis -- Dose-response modelling : basic concepts -- Dose-response modelling : why and when to use it -- Principles of dose-response modelling -- Communicating the results of dose-response modelling -- Conclusions and recommendations.".
- 2010369282 title "Principles for modelling dose-response for the risk assessment of chemicals / first draft prepared by the WHO Task Group on Environmental Health Criteria on Principles for Modelling Dose-Response for the Risk Assessment of Chemicals.".
- 2010369282 type "text".