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- 2011275018 abstract "Glutamate is the most pervasive neurotransmitter in the central nervous system (CNS). Despite this fact, no validated biological markers, or biomarkers, currently exist for measuring glutamate pathology in CNS disorders or injuries. Glutamate dysfunction has been associated with an extensive range of nervous system diseases and disorders. Problems with how the neurotransmitter glutamate functions in the brain have been linked to a wide variety of disorders, including schizophrenia, Alzheimer's, substance abuse, and traumatic brain injury. These conditions are widespread, affecting a large portion of the United States population, and remain difficult to treat. Efforts to understand, treat, and prevent glutamate-related disorders can be aided by the identification of valid biomarkers. The Institute of Medicine's Forum on Neuroscience and Nervous System Disorders held a workshop on June 21-22, 2010, to explore ways to accelerate the development, validation, and implementation of such biomarkers. This book investigates promising current and emerging technologies, and outlines strategies to procure resources and tools to advance drug development for associated nervous system disorders. Moreover, this report highlights presentations by expert panelists, and the open panel discussions that occurred during the workshop.".
- 2011275018 contributor B12162882.
- 2011275018 contributor B12162883.
- 2011275018 created "c2011.".
- 2011275018 date "2011".
- 2011275018 date "c2011.".
- 2011275018 dateCopyrighted "c2011.".
- 2011275018 description "Glutamate is the most pervasive neurotransmitter in the central nervous system (CNS). Despite this fact, no validated biological markers, or biomarkers, currently exist for measuring glutamate pathology in CNS disorders or injuries. Glutamate dysfunction has been associated with an extensive range of nervous system diseases and disorders. Problems with how the neurotransmitter glutamate functions in the brain have been linked to a wide variety of disorders, including schizophrenia, Alzheimer's, substance abuse, and traumatic brain injury. These conditions are widespread, affecting a large portion of the United States population, and remain difficult to treat. Efforts to understand, treat, and prevent glutamate-related disorders can be aided by the identification of valid biomarkers. The Institute of Medicine's Forum on Neuroscience and Nervous System Disorders held a workshop on June 21-22, 2010, to explore ways to accelerate the development, validation, and implementation of such biomarkers. This book investigates promising current and emerging technologies, and outlines strategies to procure resources and tools to advance drug development for associated nervous system disorders. Moreover, this report highlights presentations by expert panelists, and the open panel discussions that occurred during the workshop.".
- 2011275018 description "Includes bibliographical references (p. 39-43)".
- 2011275018 extent "xii, 61 p. :".
- 2011275018 hasFormat "Also available online in Open Book format via the National Academies Press home page.".
- 2011275018 identifier "0309212219".
- 2011275018 identifier "9780309212212".
- 2011275018 identifier catalog.php?record_id=13146.
- 2011275018 isFormatOf "Also available online in Open Book format via the National Academies Press home page.".
- 2011275018 issued "2011".
- 2011275018 issued "c2011.".
- 2011275018 language "eng".
- 2011275018 publisher "Washington, D.C. : National Academies Press,".
- 2011275018 relation "Also available online in Open Book format via the National Academies Press home page.".
- 2011275018 subject "615.10724 23".
- 2011275018 subject "Biochemical markers Congresses.".
- 2011275018 subject "Drug development Congresses.".
- 2011275018 subject "Nervous system Diseases Congresses.".
- 2011275018 subject "Neuropharmacology Congresses.".
- 2011275018 subject "R853.B54 G58 2011".
- 2011275018 title "Glutamate-related biomarkers in drug development for disorders of the nervous system : workshop summary / Diana E. Pankevich, Miriam Davis, and Bruce M. Altevogt, rapporteurs ; Forum on Neuroscience and Nervous System Disorders, Board on Health Sciences Policy, Institute of Medicine of the National Academies.".
- 2011275018 type "text".