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- 2011939084 contributor B12422925.
- 2011939084 created "c2012.".
- 2011939084 date "2012".
- 2011939084 date "c2012.".
- 2011939084 dateCopyrighted "c2012.".
- 2011939084 description "Includes bibliographical references and index.".
- 2011939084 description "Overview of designing genetically engineered mouse (GEM) models -- Use of Cre-loxP technology and inducible systems to generate mouse models of cancer -- Using recombineering technology to create genetically engineered mouse models -- Insertional mutagenesis for generating mouse models of cancer -- RCAS/TVA somatic gene transfer method in modeling human cancer -- Target-selected ENU mutagenesis to develop cancer models in the rat -- Tumor pathology of genetically engineered mice: genomic pathology -- Genomic DNA copy number alterations in mouse cancer models and human cancer -- Characterization of chromosomal translocations in mouse models of hematological malignancies using spectral karyotyping, FISH, and immunocytochemistry -- Expression profiling of mouse models of human cancer: model categorization and guidance for preclinical testing -- Imaging mouse models of human cancer -- Identifying mammary epithelial stem and progenitor cells -- Differentiation programs in development and cancer -- Roles of p53 and pRB tumor suppressor networks in human cancer: insight from studies in the engineered mouse -- Mouse models for colorectal cancer -- Src family tyrosine kinases: implications for mammary tumor progression -- Maspin and suppresion of tumor metastasis -- Epigenetic mouse models -- Modeling transforming growth factor-ss signalling in cancer -- Modeling stromal-epithelial interactions -- Utilizing mouse models of human cancer for assessing immune modulation of cancer development -- Transplanted tumor models for preclinical drug testing and the potential benefit of genetically engineered mouse models -- Development and use of genetically tractable preclinical mouse models -- Animal models for breast cancer prevention research -- Oncogene addiction: mouse models and clinical relevance for molecularly targeted therapies -- Mouse models in preclinical drug development: applications to CNS models -- Mouse models of human cancer: role in preclinical testing and personalized medicine -- Mighty, bow how useful? The emerging role of genetically engineered mice in cancer drug discovery and development.".
- 2011939084 extent "xx, 632 p. :".
- 2011939084 identifier "0387698035".
- 2011939084 identifier "9780387698038".
- 2011939084 identifier 2011939084-d.html.
- 2011939084 identifier 2011939084-t.html.
- 2011939084 issued "2012".
- 2011939084 issued "c2012.".
- 2011939084 language "eng".
- 2011939084 publisher "New York : Springer Verlag,".
- 2011939084 subject "Cancer Animal models.".
- 2011939084 subject "Mice Genetic engineering.".
- 2011939084 subject "Mice as laboratory animals.".
- 2011939084 subject "QH442.6 .G465 2012".
- 2011939084 subject "Transgenic mice.".
- 2011939084 tableOfContents "Overview of designing genetically engineered mouse (GEM) models -- Use of Cre-loxP technology and inducible systems to generate mouse models of cancer -- Using recombineering technology to create genetically engineered mouse models -- Insertional mutagenesis for generating mouse models of cancer -- RCAS/TVA somatic gene transfer method in modeling human cancer -- Target-selected ENU mutagenesis to develop cancer models in the rat -- Tumor pathology of genetically engineered mice: genomic pathology -- Genomic DNA copy number alterations in mouse cancer models and human cancer -- Characterization of chromosomal translocations in mouse models of hematological malignancies using spectral karyotyping, FISH, and immunocytochemistry -- Expression profiling of mouse models of human cancer: model categorization and guidance for preclinical testing -- Imaging mouse models of human cancer -- Identifying mammary epithelial stem and progenitor cells -- Differentiation programs in development and cancer -- Roles of p53 and pRB tumor suppressor networks in human cancer: insight from studies in the engineered mouse -- Mouse models for colorectal cancer -- Src family tyrosine kinases: implications for mammary tumor progression -- Maspin and suppresion of tumor metastasis -- Epigenetic mouse models -- Modeling transforming growth factor-ss signalling in cancer -- Modeling stromal-epithelial interactions -- Utilizing mouse models of human cancer for assessing immune modulation of cancer development -- Transplanted tumor models for preclinical drug testing and the potential benefit of genetically engineered mouse models -- Development and use of genetically tractable preclinical mouse models -- Animal models for breast cancer prevention research -- Oncogene addiction: mouse models and clinical relevance for molecularly targeted therapies -- Mouse models in preclinical drug development: applications to CNS models -- Mouse models of human cancer: role in preclinical testing and personalized medicine -- Mighty, bow how useful? The emerging role of genetically engineered mice in cancer drug discovery and development.".
- 2011939084 title "Genetically engineered mice for cancer research : design, analysis, pathways, validation and pre-clinical testing / Jeffrey E. Green, Thomas Ried, editors.".
- 2011939084 type "text".