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- 01JDHRA2Q2THD2P7EPC7NQ83W4 classification A1.
- 01JDHRA2Q2THD2P7EPC7NQ83W4 date "2024".
- 01JDHRA2Q2THD2P7EPC7NQ83W4 language "eng".
- 01JDHRA2Q2THD2P7EPC7NQ83W4 type journalArticle.
- 01JDHRA2Q2THD2P7EPC7NQ83W4 hasPart 01JDHRBK3E6QVCQRJH7QQQAXYG.pdf.
- 01JDHRA2Q2THD2P7EPC7NQ83W4 hasPart 01JNK5CD9QXEK88709161A2CKY.docx.
- 01JDHRA2Q2THD2P7EPC7NQ83W4 subject "Veterinary Sciences".
- 01JDHRA2Q2THD2P7EPC7NQ83W4 doi "10.1016/j.anireprosci.2024.107535".
- 01JDHRA2Q2THD2P7EPC7NQ83W4 issn "0378-4320".
- 01JDHRA2Q2THD2P7EPC7NQ83W4 issn "1873-2232".
- 01JDHRA2Q2THD2P7EPC7NQ83W4 volume "269".
- 01JDHRA2Q2THD2P7EPC7NQ83W4 abstract "This review focuses on the mechanisms of immune tolerance and antimicrobial defense in the male genital tract of the pig. Sperm cells are foreign to the immune system and, therefore, they must be protected from the immune system. The blood-testis-barrier is mediated by a physical barrier between adjacent Sertoli cells, several cell types within the testis, and interactions between immunomodulatory molecules. The blood-epididymal-barrier is composed of a physical barrier that is lined with principal cells having a network of junctional complexes in their apical lateral membrane and completed by specific transporters. The seminal plasma (SP) contains many signaling agents involved in establishing a state of immune tolerance in the female genital tract, which is essential for successful fertilization. Specific SP-proteins, however, also have proinflammatory capacities contributing to transient uterine inflammation, supporting the removal of foreign cells, possible pathogens, and excessive spermatozoa. While many different proteins and other substances present in semen can damage sperm cells, they may also protect them against viral infections. A delicate balance of these substances, therefore, needs to be maintained. Related to this, recent studies have shown the importance of extracellular vesicles (EVs), as they contain these substances and convey immune signals. Yet, viruses may use EVs to interact with the male genital tract and circumvent immune responses. For this reason, further research needs to explore the role of EVs in the male reproductive tract, as it might contribute to elucidating the pathogenesis of viral infections that might be transmitted via semen and to developing better vaccines.".
- 01JDHRA2Q2THD2P7EPC7NQ83W4 author 5B305BB6-0FE8-11E6-A633-B0D3B4D1D7B1.
- 01JDHRA2Q2THD2P7EPC7NQ83W4 author F4693438-F0ED-11E1-A9DE-61C894A0A6B4.
- 01JDHRA2Q2THD2P7EPC7NQ83W4 author F4F831BA-F0ED-11E1-A9DE-61C894A0A6B4.
- 01JDHRA2Q2THD2P7EPC7NQ83W4 author F54EFAAE-F0ED-11E1-A9DE-61C894A0A6B4.
- 01JDHRA2Q2THD2P7EPC7NQ83W4 dateCreated "2024-11-25T13:31:23Z".
- 01JDHRA2Q2THD2P7EPC7NQ83W4 dateModified "2025-03-05T12:46:58Z".
- 01JDHRA2Q2THD2P7EPC7NQ83W4 name "Immunological defense mechanisms of ejaculates and the spread of viral infectious diseases through pig semen".
- 01JDHRA2Q2THD2P7EPC7NQ83W4 pagination urn:uuid:3f25606a-ee2e-4a8a-aac8-be6f742322c8.
- 01JDHRA2Q2THD2P7EPC7NQ83W4 sameAs LU-01JDHRA2Q2THD2P7EPC7NQ83W4.
- 01JDHRA2Q2THD2P7EPC7NQ83W4 sourceOrganization urn:uuid:54666e37-428d-4ade-877b-92852c20c217.
- 01JDHRA2Q2THD2P7EPC7NQ83W4 sourceOrganization urn:uuid:89038435-24ed-4759-bfae-cbe50fac7e2d.
- 01JDHRA2Q2THD2P7EPC7NQ83W4 type A1.