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- aggregation classification "A1".
- aggregation creator B226348.
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- aggregation date "2010".
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- aggregation isPartOf urn:issn:1467-2987.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Veterinary Sciences".
- aggregation title "Cardiovascular effects following epidural injection of romifidine in isoflurane-anaesthetized dogs".
- aggregation abstract "Objective To investigate the cardiovascular effects of epidural romifidine in isoflurane-anaesthetized dogs. Study design Prospective, randomized, blinded experiment. Animals A total of six healthy adult female Beagles aged 1.25 +/- 0.08 years and weighing 12.46 +/- 1.48 (10.25-14.50) kg. Methods Anaesthesia was induced with propofol (6-9 mg kg(-1)) and maintained with 1.8-1.9% endtidal isoflurane in oxygen. End-tidal CO2 was kept between 35 and 45 mmHg (4.7-6.0 kPa) using intermittent positive pressure ventilation. Heart rate (HR), arterial blood pressure and cardiac output ( CO) were monitored. Cardiac output was determined using a LiDCO monitor and the derived parameters were calculated. After baseline measurements, either 10 mu g kg(-1) romifidine or saline ( total volume 1 mL 4.5 kg(-1)) was injected into the lumbosacral epidural space. Data were recorded for 1 hour after epidural injection. A minimum of 1 week elapsed between treatments. Results After epidural injection, the overall means (+/- standard deviation, SD) of HR ( 95 +/- 20 bpm), mean arterial blood pressure (MAP) (81 +/- 19 mmHg), CO (1.63 +/- 0.66 L minute(-1)), cardiac index (CI) (2.97 +/- 1.1 L minute(-1) m(-2)) and stroke volume index (SI) (1.38 +/- 0.21 mL beat(-1) kg(-1)) were significantly lower in the romifidine treatment compared with the overall means in the saline treatment [HR (129 +/- 24 bpm), MAP (89 +/- 17 mmHg), CO (3.35 +/- 0.86 L minute(-1)), CI (6.17 +/- 1.4 L minute(-1) m(-2)) and SI (2.21 +/- 0.21 mL beat(-1) kg(-1))]. The overall mean of systemic vascular resistance index (SVRI) (7202 +/- 2656 dynes seconds cm(-5) m(-2)) after epidural romifidine injection was significantly higher than the overall mean of SVRI (3315 +/- 1167 dynes seconds cm(-5) m(-2)) after epidural saline injection. Conclusion Epidural romifidine in isoflurane-anaesthetized dogs caused significant cardiovascular effects similar to those reportedly produced by systemic romifidine administration.".
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