Matches in UGent Biblio for { <https://biblio.ugent.be/publication/2916061#aggregation> ?p ?o. }
Showing items 1 to 41 of
41
with 100 items per page.
- aggregation classification "A1".
- aggregation creator B435146.
- aggregation creator B435147.
- aggregation creator B435148.
- aggregation creator B435149.
- aggregation creator B435150.
- aggregation creator B435151.
- aggregation creator B435152.
- aggregation creator B435153.
- aggregation creator B435154.
- aggregation creator B435155.
- aggregation creator person.
- aggregation date "2006".
- aggregation format "application/pdf".
- aggregation hasFormat 2916061.bibtex.
- aggregation hasFormat 2916061.csv.
- aggregation hasFormat 2916061.dc.
- aggregation hasFormat 2916061.didl.
- aggregation hasFormat 2916061.doc.
- aggregation hasFormat 2916061.json.
- aggregation hasFormat 2916061.mets.
- aggregation hasFormat 2916061.mods.
- aggregation hasFormat 2916061.rdf.
- aggregation hasFormat 2916061.ris.
- aggregation hasFormat 2916061.txt.
- aggregation hasFormat 2916061.xls.
- aggregation hasFormat 2916061.yaml.
- aggregation isPartOf urn:issn:0161-5505.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Technology and Engineering".
- aggregation title "Initial infarct size predicts subsequent cardiac remodeling in the rat infarct model: an in vivo serial pinhole gated SPECT study".
- aggregation abstract "The rat infarct model is widely used to study left ventricular (LV) remodeling, a main cause of heart failure characterized by progressive LV dilatation. Using pinhole collimators and advances in data processing, gated SPECT was recently adapted to image the rat heart. The aim of this study was to assess this new imaging technique for predicting and quantifying variable LV remodeling from the rat infarct model. Methods: Pinhole Tc-99m-sestamibi gated SPECT was validated for determining LV volume and identifying the necrotic and nonviable LV segments (<50% of Tc-99m-sestamibi uptake) in rats, and it was applied to monitor rat LV function from 48 h to 12 wk after occlusion of the left anterior descending coronary artery (LAD) (n = 20) or sham operation (n = 9). Results: In LAD-occluded rats, 48-h SPECT necrosis was large (>= 30% LV) in 6, limited (<30% LV) in 6, and undetectable in 8. End-diastolic volume of LAD-occluded rats was equivalent to that of sham-operated rats at 48 h (320 +/- 84 mu L vs. 293 +/- 48 mu L; not significant) but became higher at 12 wk (501 +/- 191 mu L vs. 343 +/- 46 mu L; P = 0.01). The follow-up increase in end-diastolic volume, which reflects the remodeling process, was closely related to the initial extent of necrosis revealed by the SPECT images (P < 0.001; R-2 = 0.85). This increase was limited in sham-operated rats (50 +/- 15 mu L) and in the LAD-occluded rats with undetectable necrosis (55 +/- 35 mu L) but it was around 3- and 7-fold higher in the LAD-occluded rats with limited (165 +/- 57 mu L) and large (366 +/- 113 mu L) necrosis, respectively. Conclusion: The variable LV remodeling documented after coronary occlusion in rats closely relates to the variable extent of necrosis provided by this model. Pinhole gated SPECT allows this remodeling to be predicted and quantified and, hence, constitutes an original tool for the experiments scheduled on the rat infarct model.".
- aggregation authorList BK758275.
- aggregation endPage "344".
- aggregation issue "2".
- aggregation startPage "337".
- aggregation volume "47".
- aggregation aggregates 3132721.
- aggregation isDescribedBy 2916061.
- aggregation similarTo LU-2916061.