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- aggregation classification "A1".
- aggregation creator B257187.
- aggregation creator B257188.
- aggregation creator B257189.
- aggregation creator person.
- aggregation date "2012".
- aggregation format "application/pdf".
- aggregation hasFormat 2967018.bibtex.
- aggregation hasFormat 2967018.csv.
- aggregation hasFormat 2967018.dc.
- aggregation hasFormat 2967018.didl.
- aggregation hasFormat 2967018.doc.
- aggregation hasFormat 2967018.json.
- aggregation hasFormat 2967018.mets.
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- aggregation hasFormat 2967018.xls.
- aggregation hasFormat 2967018.yaml.
- aggregation isPartOf urn:issn:1932-6203.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Social Sciences".
- aggregation title "Thermal detection thresholds of a delta- and C-Fibre afferents activated by brief CO2 laser pulses applied onto the human hairy skin".
- aggregation abstract "Brief high-power laser pulses applied onto the hairy skin of the distal end of a limb generate a double sensation related to the activation of A delta- and C-fibres, referred to as first and second pain. However, neurophysiological and behavioural responses related to the activation of C-fibres can be studied reliably only if the concomitant activation of A delta- fibres is avoided. Here, using a novel CO2 laser stimulator able to deliver constant-temperature heat pulses through a feedback regulation of laser power by an online measurement of skin temperature at target site, combined with an adaptive staircase algorithm using reaction-time to distinguish between responses triggered by A delta- and C-fibre input, we show that it is possible to estimate robustly and independently the thermal detection thresholds of A delta- fibres (46.9 +/- 1.7 degrees C) and C-fibres (39.8 +/- 1.7 degrees C). Furthermore, we show that both thresholds are dependent on the skin temperature preceding and/or surrounding the test stimulus, indicating that the A delta- and C-fibre afferents triggering the behavioural responses to brief laser pulses behave, at least partially, as detectors of a change in skin temperature rather than as pure level detectors. Most importantly, our results show that the difference in threshold between A delta- and C-fibre afferents activated by brief laser pulses can be exploited to activate C-fibres selectively and reliably, provided that the rise in skin temperature generated by the laser stimulator is well-controlled. Our approach could constitute a tool to explore, in humans, the physiological and pathophysiological mechanisms involved in processing C-and A delta- fibre input, respectively.".
- aggregation authorList BK532669.
- aggregation issue "4".
- aggregation volume "7".
- aggregation aggregates 2967024.
- aggregation isDescribedBy 2967018.
- aggregation similarTo journal.pone.0035817.
- aggregation similarTo LU-2967018.