Matches in UGent Biblio for { <https://biblio.ugent.be/publication/5734020#aggregation> ?p ?o. }
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- aggregation classification "A1".
- aggregation creator B982479.
- aggregation creator B982480.
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- aggregation creator person.
- aggregation date "2005".
- aggregation format "application/pdf".
- aggregation hasFormat 5734020.bibtex.
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- aggregation isPartOf urn:issn:0022-1007.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Biology and Life Sciences".
- aggregation title "RAGE limits regeneration after massive liver injury by coordinated suppression TNF-α and NF-κB".
- aggregation abstract "The exquisite ability of the liver to regenerate is finite. Identification of mechanisms that limit regeneration after massive injury holds the key to expanding the limits of liver transplantation and salvaging livers and hosts overwhelmed by carcinoma and toxic insults. Receptor for advanced glycation endproducts (RAGE) is up-regulated in liver remnants selectively after massive (85%) versus partial (70%) hepatectomy, principally in mononuclear phagocyte-derived dendritic cells (MPDDCs) Blockade of RAGE, using pharmacological antagonists or transgenic mice in which a signaling-deficient RAGE mutant is expressed in cells of mononuclear phagocyte lineage, significantly increases survival after massive liver resection. In the first hours after massive resection, remnants retrieved from RAGE-blocked mice displayed increased activated NF-kappaB principally in hepatocytes, and enhanced expression of regeneration-promoting cytokines, TNF-alpha and IL-6 and the antiinflammatory cytokine, IL-10. Hepatocyte proliferation was increased by RAGE blockade, in parallel with significantly reduced apoptosis. These data highlight central roles for RAGE and MPDCCs in modulation of cell death-promoting mechanisms in massive hepatectomy and suggest that RAGE blockade is a novel strategy to promote regeneration in the massively injured liver.".
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- aggregation endPage "484".
- aggregation issue "3".
- aggregation startPage "473".
- aggregation volume "201".
- aggregation aggregates 5735751.
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