Matches in UGent Biblio for { <https://biblio.ugent.be/publication/878774#aggregation> ?p ?o. }
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- aggregation classification "A1".
- aggregation creator B330444.
- aggregation creator B330445.
- aggregation creator B330446.
- aggregation creator person.
- aggregation creator person.
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- aggregation creator person.
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- aggregation date "2010".
- aggregation format "application/pdf".
- aggregation hasFormat 878774.bibtex.
- aggregation hasFormat 878774.csv.
- aggregation hasFormat 878774.dc.
- aggregation hasFormat 878774.didl.
- aggregation hasFormat 878774.doc.
- aggregation hasFormat 878774.json.
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- aggregation hasFormat 878774.txt.
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- aggregation hasFormat 878774.yaml.
- aggregation isPartOf urn:issn:1553-7390.
- aggregation language "eng".
- aggregation publisher "PUBLIC LIBRARY SCIENCE".
- aggregation rights "I don't know the status of the copyright for this publication".
- aggregation subject "Biology and Life Sciences".
- aggregation title "The MCM-Binding Protein ETG1 Aids Sister Chromatid Cohesion Required for Postreplicative Homologous Recombination Repair".
- aggregation abstract "The DNA replication process represents a source of DNA stress that causes potentially spontaneous genome damage. This effect might be strengthened by mutations in crucial replication factors, requiring the activation of DNA damage checkpoints to enable DNA repair before anaphase onset. Here, we demonstrate that depletion of the evolutionarily conserved minichromosome maintenance helicase-binding protein ETG1 of Arabidopsis thaliana resulted in a stringent late G2 cell cycle arrest. This arrest correlated with a partial loss of sister chromatid cohesion. The lack-of-cohesion phenotype was intensified in plants without functional CTF18, a replication fork factor needed for cohesion establishment. The synergistic effect of the etg1 and ctf18 mutants on sister chromatid cohesion strengthened the impact on plant growth of the replication stress caused by ETG1 deficiency because of inefficient DNA repair. We conclude that the ETG1 replication factor is required for efficient cohesion and that cohesion establishment is essential for proper development of plants suffering from endogenous DNA stress. Cohesion defects observed upon knockdown of its human counterpart suggest an equally important developmental role for the orthologous mammalian ETG1 protein.".
- aggregation authorList BK623045.
- aggregation issue "1".
- aggregation volume "6".
- aggregation aggregates 2937196.
- aggregation isDescribedBy 878774.
- aggregation similarTo journal.pgen.1000817.
- aggregation similarTo LU-878774.