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- aggregation classification "A1".
- aggregation creator B435957.
- aggregation creator B435958.
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- aggregation creator person.
- aggregation date "2009".
- aggregation format "application/pdf".
- aggregation hasFormat 879831.bibtex.
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- aggregation isPartOf urn:issn:1932-6203.
- aggregation language "eng".
- aggregation publisher "PUBLIC LIBRARY SCIENCE".
- aggregation subject "Medicine and Health Sciences".
- aggregation title "Quality-Controlled Small-Scale Production of a Well-Defined Bacteriophage Cocktail for Use in Human Clinical Trials".
- aggregation abstract "We describe the small-scale, laboratory-based, production and quality control of a cocktail, consisting of exclusively lytic bacteriophages, designed for the treatment of Pseudomonas aeruginosa and Staphylococcus aureus infections in burn rounds three bacteriophages were retained from an initial pool of 82 P.aeruginosa and 8 S. aureus bacteriophages, specific for prevalent P.aeruginosa and S. aureus strains in the Burn Centre of the Queen Astrid Military Hospital in Brussels, Belgium. This cocktail, consisting of P.aeruginosa phages 14/1 (Myoviridae) and PNM (Podoviridae) and S. aureus phage ISP (Myoviridae) was produced and purified of endotoxin. Quality control included Stability (shelf life), determination of pyrogenicity, sterility and cytotoxicity, confirmation of the absence of temperate bacteriophages and transmission electron microscopy-based confirmation of the presence of the expected virion morphologic particles as well as of their specific interaction with the target bacteria. Bacteriophage genome and proteome analysis confirmed the lytic nature of the bacteriophages, the absence of toxin-coding genes and showed that the selected phages 14/1, PNM and ISP are close relatives of respectively F8, phi KMV and phage G1. The bacteriophage cocktail is currently being evaluated in a pilot clinical study cleared by a leading Medical Ethical Committee.".
- aggregation authorList BK759899.
- aggregation issue "3".
- aggregation volume "4".
- aggregation aggregates 882113.
- aggregation isDescribedBy 879831.
- aggregation similarTo journal.pone.0004944.
- aggregation similarTo LU-879831.